Posted by Caleb462 on August 25, 2003, at 13:24:35
In reply to Re: Salvia divinorum, posted by Ame Sans Vie on August 25, 2003, at 7:08:13
"We discovered that Salvinorin A potently and selectively inhibited (3)H-bremazocine binding to cloned kappa opioid receptors. Salvinorin A had no significant activity against a battery of 50 receptors, transporters, and ion channels and showed a distinctive profile compared with the prototypic hallucinogen lysergic acid diethylamide. Functional studies demonstrated that Salvinorin A is a potent kappa opioid agonist at cloned kappa opioid receptors expressed in human embryonic kidney-293 cells and at native kappa opioid receptors expressed in guinea pig brain. Importantly, Salvinorin A had no actions at the 5-HT(2A) serotonin receptor, the principal molecular target responsible for the actions of classical hallucinogens"
poster:Caleb462
thread:253743
URL: http://www.dr-bob.org/babble/20030823/msgs/253897.html