Posted by Caleb462 on August 25, 2003, at 13:19:31
In reply to Re: Salvia divinorum, posted by Ame Sans Vie on August 25, 2003, at 7:08:13
> In my experience, a S.D. trip is extremely similar to an acid trip -- just way more intense. All the usual characteristics of the LSD trip are present -- altered thought processes, deep introspection, brightened colors, intense open-eye visuals, and even more intense closed-eye visuals. The only thing really missing is that speedy type of feeling LSD provides... so in that regard, salvia is a bit more like psilocybe mushrooms.
>
> As far as I know, the pharmacolical mechanisms of salvinorum A and LSD are almost identical: while the jury's still out on *exactly* how they operate on these receptors, both drugs affect 5HT1 and 5HT2 primarily. The debate seems kind of funny, though... they can't figure out whether the drugs are agonistic or antagonistic at 5HT2. :-\You sure about that? From my understanding salvinorin A is a kappa opiod agonist, and has no affinity for 5-HT receptors. I certainly could be wrong...
poster:Caleb462
thread:253743
URL: http://www.dr-bob.org/babble/20030823/msgs/253895.html