Posted by Ritch on June 17, 2003, at 13:07:48
In reply to Re: What is it about Zyprexa that makes it so sedating, posted by Caleb462 on June 17, 2003, at 0:30:53
> > > > Thanks, but I'm still confused a little. What exactly does high affinity mean? I thought it meant the degree of attraction to a specific receptor, but from your post, it sounds like I've got that wrong. Please explain if you can.
> > >
> > > No, you've got it right.
> > >
> > >
> >
> > i'm curious as to what is going on in the physical sense..... i mean receptors don't really 'attract' molecules right?
> > hmmm
>
> I should have stated this - affinity means how a molecule FITS in a receptor. I think that is all there is to it, but I could be wrong.. anyone care to enlighten?Ok-I read this a LONG time ago, but from what I remember the "numbers" that you see (with regard to "affinity") have to do indirectly with the number of molecules of a given substance it takes to bind to 50% of the receptors (I think outside the body in a dish-but it is close enough analog of what happens in the body that it is useful info). So a high number means that a LOT of the substance is required to bind to 50% of the receptors or something along those lines. Of course-this needs to be clarified a lot, I'm sure, but I think that *generally* that is somewhat true.
poster:Ritch
thread:234389
URL: http://www.dr-bob.org/babble/20030614/msgs/234570.html