Posted by avid abulia on June 16, 2003, at 14:03:47
In reply to Re: Obsessively looking, posted by Caleb462 on June 16, 2003, at 11:57:04
> > First, Caleb, you said "Clomipramine is also a 5-HT2a antagonist. Thus you get multiple Anti-depressant/Anti-obsessional effects from the same drug." i thought 5-HT2 (including 5-HT2a i think) agonism helps obsessive-compulsive tendencies and 5-HT2 antagonism aggravates OC stuff. Am i wrong on this or are you (/him)? Please, i'm really curious about this.
>
> Well... it's complex. There has been some information that 5-HT2a agonists may help OCD - because there are many ancedotal reports of LSD and other 5-HT2a/c agonists alleviating OCD symptoms. And atypical anti-psychotics have been shown to worsen OCD when used alone - without an SRI. When an SRI and a 5-HT2 blocker are combined, however, there doesn't seem to be any problem - and indeed, it seems to boost the anti-obsessional effects.
it also partially depends on your type of OCD. if you have OCD occurring in conjunction with tics or a family history of tics, 5-ht2a antagonism, along with D2 antagonism, can significantly improve symptoms without an SRI. risperdal has the most studies in this regard.>
>
> > BekkaH said:
> > > "I was much more obsessive-compulsive when I was on Adderall.although some people report feeling worse on a stimulant if they have OCD, a small subset does significantly better with stimulant augmentation... which may partially explain the efficacy of Parnate in many individuals.
~AA
poster:avid abulia
thread:234054
URL: http://www.dr-bob.org/babble/20030614/msgs/234358.html