Posted by ace on June 14, 2003, at 1:43:03
In reply to can anyone help with this?, posted by avid abulia on June 14, 2003, at 0:09:55
> i am not doing all that well off of my AD though withdrawal is over (my body adjusts to med changes quite quickly, who knows why)... mostly, my OCD is getting a lot worse, but i am also depressed.
>
> i react quite poorly to SSRIs (hostility and self injury/suicidal thoughts), have had positive responses to wellbutrin (only for depression), effexor (only for OCD), and higher doses of inversine (for both), but experienced seizure exacerbation. i have not tried TCAs or MAOIs as of yet, nor have i tried serzone or remeron. the typical and atypical antipsychotics and i are no match made in heaven. i am a cyp 450 3a4 poor metabolizer as well. my current meds are lamictal 200mg b.i.d. keppra 1000mg b.i.d. inversine 2.5mg b.i.d. and diazepam prn (generally 1.25-2.5 mg and quite rarely up to 10mg qhs-b.i.d. for tics, anxiety, insomnia, seizures or migraine--a real all-arounder for me) and parenteral morphine/phenergan/toradol, 15/25/60mg respectively prn (generally once or twice per month or two for severe basilar migraine).
>
> does anyone know a drug or drug combo or a change that may be useful that may help with depression and OCD with a relatively low risk of seizure, tic, and migraine exacerbation?Yes! An MAOI (Nardil or Parnate - I'd go Nardil first) Anafranil low dose (due to its problems with seizures). Have you tried Zyprexa or any old typical APs? Any luck?
But not just from my experience, but from the many, many, many anecdotes I've read I would say give Nardil a try. More thought but I'm about to be kicked out of my library (closing time!)
All the best,
Ace.> ~AA
poster:ace
thread:233876
URL: http://www.dr-bob.org/babble/20030609/msgs/233887.html