Posted by samplemethod on June 7, 2003, at 23:10:55
In reply to Re: MSG and aspartame etc » samplemethod, posted by Larry Hoover on June 7, 2003, at 17:33:51
Yeh have the same reaction to hyperbolic websites.
What I will do is trial reducing MSG and aspartame.
Lar, can you explain your reasoning about avoiding the excitatory glutamate and aspartate substances in light of you taking NADH and TMG.
I sort of read somewhere about altering the NMDA receptors, when taking both glycine and glutamate. During a period of major head sluggishness and motivation after eating anything (which is not my usual reaction), and at a time I had the glycinate form of mag in my diet, I thought to myself the glycine from the glycinate and the glutamate from the MSG was stuffing me up.Check out this info below to get to know what I mean.
http://www.burnham-inst.org/TechnologyTransfer/LicensingOpportunities/LicensingOpportunitiesReports/NovelGlycineReceptor.asp
NOVEL GLYCINE RECEPTOR Principal Investigators: Stuart A. Lipton, M.D., Ph.D. <../../../FacultyAndResearch/Faculty/stuart_lipton_bio.asp> and Dongxian Zhang, Ph.D. <../../../FacultyAndResearch/Faculty/dongxian_zhang_bio.asp> Application: Neurological, Ion Channels Invention: Scientists at The Burnham Institute have discovered the final member of subunits in this family of receptors, called NR3B. Institute scientists have also discovered novel functional, excitatory glycine receptor which is created by using a combination of NMDAR subunits. Patent Status: US and Foreign Patents pending. Background: NMDA receptors (NMDAR) are glutamate receptors which are well known in the field of Neurobiology as ligand gated cation channel receptors which mediate the excitatory nervous response in the CNS. NMDARs, unlike other glutamate receptors require the presence of dual agonists: glutamate and glycine. NMDARs are extremely important in the development of the nervous system, synaptic plasticity, memory and other CNS processes; but excessive stimulation of NMDARs has been implicated in many pathological conditions (stroke, ischemia, glaucoma, depression, Alzheimer’s disease, Huntington disease, etc.). The current NMDA receptor subunits are inadequate to explain the entire pharmacology of these receptors.Previously, only inhibitory glycine receptors had been found and characterized, this is the first known glycine receptor that is not responsive to glutamate. These glycine receptors are far less permeable to calcium ions than previously known NMDARs. This discovery can be used to screen for inhibitors and agonists of this new type of excitatory glycine receptor. Various functions have been hypothesized for this new type of receptor and research is underway to characterize the physiological function of this new type of receptor. The new subunits that have been cloned by Institute scientists, designated NR3 subunits, have two properties of interest: (1) they can antagonize NMDAR-mediated currents if expressed with the known NR1 and NR2 subunits. A knock out mouse of at least one NR3 subunit results in overactivation of NMDARs and seizures; and (2) if expressed with NR1 alone, NR3 produces the excitatory glycine receptor discussed above. References: Chatterton, J., et al., Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits, Nature 2002; 415: 793-798.
Sasaki YF, et al. Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cerebrocortical neurons. J Neurophysiol. 2002;87:2052-2063.
Pérez-Otaño I, et al. Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors. J Neurosci 2001 21:1228-1237.
Das S, et al. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature (London) 1998;393:377-381.
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> > I have recently heard about the supposed bad affects from Glutamic acid and aspartic acid. I dont know much about it, and all the websites I go to such as http://www.truthinlabeling.org/WebSites.html seem to be websites that are sensationalist and lack authority.
>
> Agreed. By over-extending into hyperbole, they lose credibility altogether. It's hard to find the truth, given the choice between hyperbole on the one hand, and the "industrial-food-processing-complex" whitewash on the other.
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> > What do u guys think about the whole MSG/aspartate deal??
>
> OK, here's my super-simplistic summary statement: Avoid them if they cause you problems.
>
> One of the coping strategies that is a core part of my wellness-program is stress reduction. In more than trace amounts, glutamate and aspartate can be stressors. They are excitatory, and in some respects, may be thought to mimic adrenergic excitation. Why "accept" them into my diet?
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> > Anyone had good effects from changing their diet?
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> Given that you're most likely to run into these bad boys in the context of processed food, I already know I do better on my own home-cookin', so the question is somewhat moot. However, if I eat out, I can pretty much tell you how much hydrolyzed protein is in the meal. I'm pretty sensitive to it.
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> Lar
>
>
poster:samplemethod
thread:232138
URL: http://www.dr-bob.org/babble/20030604/msgs/232298.html