Posted by jemma on May 28, 2003, at 10:01:12
In reply to Re: Running out of med options..., posted by SLS on May 27, 2003, at 18:57:43
Hi Scott -For the moment, I'm back on a modafinil ritalin sr cocktail. I hate the rebound off the ritalin, though, and I get bruxism and muscle tightness. When I see my pdoc in a week, I'm going to suggest trying wellbutrin again along with 200 mg modafinil. I tried wellbutrin before - all the way up to 450 for eight weeks - and felt nothing, no side effects, just a bit of sleepiness. I'm wondering if modafinil might work synergistically with it, as it seems to do with almost everything.
What meds are you on these days? If I recall, don't you also suffer from anergic bipolar depression?
- Jemma
> Hi Jemma.
>
> > I took a combination of low-dose selegiline (10 mg) and modafinil (200 mg) and it did wonders for my ADD AND my depression. I'd still be on it if I hadn't developed peripheral edema, an occasional side-effect of selegiline.
>
> Well, that certainly stinks.
>
> > It seems to me that low-dose selegiline is often overlooked because it's tainted with the food-restriction label, even though it doesn't apply. It took about two weeks for the good effects to kick in, but they were strong and very positive. For a while, I felt more calm, cheerful, awake and clear-headed than I ever have in my life. The modafinil and selegiline may well have been synergistic, as each is an augmenter.
>
> A friend of mine has found 5.0mg of selegiline to be very helpful for his dysthymia (minor depression) and CSF (chronic fatigue syndrome). It seems to work synergistically with the amisulpiride and Adderall he takes.
>
> > Another reason low-dose selegiline may be overlooked is that people don't realize they have to take it with food. The presence of food in the stomach augments the effect as much as tenfold for some reason.
>
> It is too bad that the selegiline patch has not been approved. It seems to make for a better antidepressant and avoids the necessity for food restrictions.
>
> > Selegiline does so many good things for the brain besides inhibiting dopamine breakdown. It increases NO, or nitric oxide, which has various beneficial effects including vasodilation, which permits much more oxygen uptake. It's also a powerful antioxidant, and has been shown to be especially protective of those fragile dopamine neurons. All in all, a wonderful drug.
>
> What are you taking now in place of selegiline?
>
>
> - Scott
>
poster:jemma
thread:550
URL: http://www.dr-bob.org/babble/20030525/msgs/229693.html