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Re: Running out of med options...

Posted by jemma on May 27, 2003, at 10:29:11

In reply to Re: Running out of med options... » lmm2003, posted by SLS on May 25, 2003, at 9:28:51

> Hi lmm2003.
>
> I just wanted you to know that your post has not been ignored. I'm sure your situation is not at all hopeless. There are plenty of things you haven't tried. I guess no one has yet been struck with an idea specific to your case. Part of the frustration must lie in the fact that you have not been given a definitive diagnosis. In your case, it is important to ascertain whether or not you really suffer from ADHD. Without knowing this, it is difficult to recommend a specific treatment.
>
> Selegiline is a drug that has certainly helped some people. However, I don't consider it to be an antidepressant with a high success rate. If depression is your main complaint, I would consider Parnate instead. You *can* combine Parnate with a stimulant like Ritalin or Adderall. Selegiline has been used to treat ADHD, but I don't know how effective it is. The NIMH tested Selegiline for ADHD at dosages between 20mg and 60mg. At this dosage, there is no advantage in terms of the necessity to follow the special diet. The diet would have to be adhered to for both Parnate and oral selegiline. It seems that inhibition of MAOI-A is necessary to treat both depression and ADHD.
>
>
> - Scott

Hi Scott -

I took a combination of low-dose selegiline (10 mg) and modafinil (200 mg) and it did wonders for my ADD AND my depression. I'd still be on it if I hadn't developed peripheral edema, an occasional side-effect of selegiline.

It seems to me that low-dose selegiline is often overlooked because it's tainted with the food-restriction label, even though it doesn't apply. It took about two weeks for the good effects to kick in, but they were strong and very positive. For a while, I felt more calm, cheerful, awake and clear-headed than I ever have in my life. The modafinil and selegiline may well have been synergistic, as each is an augmenter.

Another reason low-dose selegiline may be overlooked is that people don't realize they have to take it with food. The presence of food in the stomach augments the effect as much as tenfold for some reason.

Selegiline does so many good things for the brain besides inhibiting dopamine breakdown. It increases NO, or nitric oxide, which has various beneficial effects including vasodilation, which permits much more oxygen uptake. It's also a powerful antioxidant, and has been shown to be especially protective of those fragile dopamine neurons. All in all, a wonderful drug.

- Jemma


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