Posted by Ron Hill on May 26, 2003, at 1:21:50
In reply to Re: new!! - Intro - NADH bitch RON, Caleb, posted by samplemethod on May 25, 2003, at 19:36:57
Sample,
> Its fairly good i think. about 3-4 hours of soccer/basketball medium aerobic level. Not much weight training at the moment.
Sounds great.
> Got any info about exercise affects upon me.Here's some interesting information about exercise taken from the web page at http://www.psycheducation.com/mechanism/introduction%20to%20mechanism.htm :
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Finally we have arrived at the new "discovery" of the last several years of research. This is the part that's not "for sure" yet, but looks very probable. It all centers, for now, around this "brain derived neurotrophic factor" (BDNF). This is the molecule that antidepressants increase, that depression appears to decrease, and that other effective antidepressants like ECTDuman(d) , exerciseOliff , and rTMS Muller also increase. What is this molecule and what does it do?As it sounds, this is a molecule that "trophs" neurons. What do "trophs" do? This term comes from the Greek word trophe, which means nourishment. A trophic factor is a molecule that somehow stimulates or allows neurons to feed, to grow, and to flourish. Without such factors neurons decrease in activity and connections to other cells. Both lithium and valproate, mood stabilizers used in bipolar disorder, increase another neurotrophic factor called bcl-2. Estrogen is another neurotrophic factor! Unfortunately, we don't know exactly what to do with that fact, but as we learn, I'll keep you posted on the Hormones and Mood site.
So, we just learned that the end effect of taking an antidepressant -- or regular exercise, or ECT, or rTMS -- is to increase BDNF; and that when the cell nucleus makes more BDNF, it helps nourish the neuron. The neuron becomes more active and makes more connections to other cells.
And this is really the only part of the story that's still uncertain. Is that the "last step"? Is it really BDNF that is the "final common path" by which all effective antidepressant approaches work? If that's so, then psychotherapy, which also definitely works in depression, ought to increase BDNF too. That hasn't been tested yet and probably won't be anytime soon (the therapy people and the molecular people are not across the hall from one another).
If you want to see some nifty pictures of BDNF itself, and see Prozac maintaining BDNF levels under stress, go on. Otherwise, you can go back to the menu of options here at PsychEducation.org.
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What did you decide about trying approximately 250 mg/day of TMG? Also, do you think the niacinamide and/or niacin is worth continuing?
-- Ron
poster:Ron Hill
thread:228795
URL: http://www.dr-bob.org/babble/20030525/msgs/229168.html