Posted by Caleb462 on May 24, 2003, at 17:22:18
In reply to Caleb, Re: Larry Hoover, posted by McPac on May 24, 2003, at 14:58:25
> "Are you sure you've got your information right? All the agents you listed should improve TD symptoms, not worsen them".
>
> (DOWN near the bottom...I could give you the link if you'd want it)
>
> TABLE 1: The Differential Pharmacology of Tardive Dyskinesia
> Agents that suppress tardive dyskinesia
> specific agents
>
> Dopamine antagonists
> Butyrophenones, clozapine, metoclopramide (Karp 1981), papaverine (mechanism uncertain), phenothiazines, bromocriptine, pimozide
>
> Dopamine D2 Agonists
> Buspirone
>
> Amine-depleting agents
> Reserpine, tetrabenzine
>
> Blocker of catecholamine synthesis
> Alpha-methyldopa, Alpha-methyltyrosine (AMPT)
>
> Blocker of catecholamine release
> Lithium salts
>
> Cholinergic agents
> Deanol (mechanism uncertain), physostigmine, choline and lecithin
>
> GABA agonists
> Progabide (Bartholini 1983), valproic acid (mechanism uncertain), baclofen (mechanism uncertain), iazepam, clonazepam
>
> Anticholinergic agents (Moore and Bowers 1980)
> Benztropine, trihexyphenidyl
>
> Agents with variable, negligible, or uncertain effects
> Alpha-methyldopa, Amantadine, Anticholinergics Antihistamines, Apomorphine, Barbiturates, Benzodiazepines, Methylphenidate, Penicillamine, Physostigmine, Pyridoxine (B6), Tryptophan, a-tocopherol (Vitamin E)
>
> Agents that worsen tardive dyskinesia
> Anticholinergic agents, Antiparkinson agents (e.g., benztropine), Dopamine agonists, Amphetamines, L-DOPA
>
> Newer investigational agents (peptides) (Blurn and Korczyn 1983)
> Endopioids, Substance P, Cholecystokinin, Ceruletide, Neurotensin, Cyclo-Leucine-Glycine
>
>Hmm... well, the site that you pulled this from is just plain wrong.
"Agents that suppress tardive dyskinesia
specific agents
Dopamine antagonists
Butyrophenones, clozapine, metoclopramide (Karp 1981), papaverine (mechanism uncertain), phenothiazines, bromocriptine, pimozide"Dopamine antagonists don't suppress TD, they CAUSE TD!! Whatever site this is from is all backwards.
poster:Caleb462
thread:228730
URL: http://www.dr-bob.org/babble/20030520/msgs/228917.html