Posted by McPac on May 24, 2003, at 14:58:25
In reply to Re: Larry Hoover, posted by Caleb462 on May 24, 2003, at 0:24:43
"Are you sure you've got your information right? All the agents you listed should improve TD symptoms, not worsen them".
(DOWN near the bottom...I could give you the link if you'd want it)
TABLE 1: The Differential Pharmacology of Tardive Dyskinesia
Agents that suppress tardive dyskinesia
specific agents
Dopamine antagonists
Butyrophenones, clozapine, metoclopramide (Karp 1981), papaverine (mechanism uncertain), phenothiazines, bromocriptine, pimozide
Dopamine D2 Agonists
Buspirone
Amine-depleting agents
Reserpine, tetrabenzine
Blocker of catecholamine synthesis
Alpha-methyldopa, Alpha-methyltyrosine (AMPT)
Blocker of catecholamine release
Lithium salts
Cholinergic agents
Deanol (mechanism uncertain), physostigmine, choline and lecithin
GABA agonists
Progabide (Bartholini 1983), valproic acid (mechanism uncertain), baclofen (mechanism uncertain), iazepam, clonazepam
Anticholinergic agents (Moore and Bowers 1980)
Benztropine, trihexyphenidyl
Agents with variable, negligible, or uncertain effects
Alpha-methyldopa, Amantadine, Anticholinergics Antihistamines, Apomorphine, Barbiturates, Benzodiazepines, Methylphenidate, Penicillamine, Physostigmine, Pyridoxine (B6), Tryptophan, a-tocopherol (Vitamin E)
Agents that worsen tardive dyskinesia
Anticholinergic agents, Antiparkinson agents (e.g., benztropine), Dopamine agonists, Amphetamines, L-DOPA
Newer investigational agents (peptides) (Blurn and Korczyn 1983)
Endopioids, Substance P, Cholecystokinin, Ceruletide, Neurotensin, Cyclo-Leucine-Glycine
poster:McPac
thread:228730
URL: http://www.dr-bob.org/babble/20030520/msgs/228882.html