Re: Why Dirty Drug

Posted by SLS on May 1, 2003, at 8:51:19

In reply to Why Dirty Drug » SLS, posted by jack smith on April 30, 2003, at 17:01:40

Hi Jack.
> Scott, or others, why are TCA's and MAOI's referred to as dirty drugs? I have never quite understood this. Is it just because they are not selective.
Yes - and that the additional undesirable actions cause side-effects. Anafranil binds to and blocks many receptors, including histamine H1 (antihistaminergic) and acetylcholine (anticholinergic}. These two actions account for things like sedation, weight-gain, dry mouth, and constipation.
- Scott

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