Posted by LAURA777 on February 6, 2003, at 19:21:52
In reply to Re: stimulants / anhedonia » LAURA777, posted by not exactly on February 6, 2003, at 16:32:20
Hey bob , i found out incredible things today ..first i have high norepinephrine . this is know because my metabolism is very fast . i remain skinny although i eat .. i have energy but the anhedonia makes me tired because of the boredom and the fact that there is no temperance with the pleasant emotions .. initially i was put on prozac because of my excess energy .. i am not add nor am i adhd .. it is just in my natural state i am revved up ..go go go gota go ..The ssris have done a good job with this , it has put my noreprinephrine in check .. but i am still very sensitive to stimulants , i can not take cold meds with psedoephedrine , i feel horrid both emotional like the coke thing smaller scale and physcally .. Provigil is way too much for me .. it gives me energy , but nervous useless energy.. physically i do not feel well either , and this is due to the norepinephrine i have already .. this neurotransmitter is responsible for energy , metabolisim .. people who have fast metabolisim have lots of norepinephrine .. another proof of this is at the dental office when they give you novicaine they add what is called epinephrine .. it prolongs the novicaine effect , when i get this my heart pounds in my chest i shake and i get halos in my vision similar to migraine auras ...it is a scary thing ... my mother is also reactive this way to epinephrine ... these substances are all related .. i looked it up .. ephedrine and psuedoehedrine act of norepinephrine in our brains ,, ehedrine being a natural substance in herbs can cause very bad effects in a normal person .. it speeds up heart rate because it acctivates norepinephrine as does psuedoephdrine ..epinephrine and norepi act in conjuction , that is why you hear on emergency room shows when someones heart stops they say give me a vial of epi .... i have never coralated this before in my life with such clarity as i surfed the net .. that is why when they gave me effexor i had a bad reaction same goes for the wellbutrin .... none of these meds touch the dopamine , and as far as effecting dopamine levels inadvertantly it is not enough , i do not think alot of people have a dopamine deficit , hence the 70 percent response to ssri and snris when treating depression soley .. here is an interesting read the link is below ..
http://www.acnp.org/g4/GN401000093/CH.html
this is a good read because in mania dopamine is at a high in the brain . same with schiz when they are in the wild end .. antipsychotics reverse this .. so much so with schiz that they get severe apathy and anhedonia .. what makes me laugh is that i read a study involving depressives and schiz depressives .. the depressives measured very low on the serotonin scale . they measure this by some by product produced from the sero .. any way the measured the schiz depressives and the had high levels of sero .. that thought this strange .. i had to laugh .. how could they not see !! if you take away dopamine because of adverse schiz states serotonin is going to increase .. but lack of dopamine causes this negitive state of schiz , i guess that is why afiliby is a better treatment for them ...the upshot of all this is that dopamine is essential and not to be discarded for study as was previously thought ... noro and sero are not the end all for the depressive . they have to develop a good dopaminergic that targets the area of the mesolimbic , and i also think they need to investigate the opiates and created better drugs like buprenorphine .. i mean we use snake venom for anti venom .. i know if they put some time into it they could do this , it is just that profits are important and when you are talking opiate there is a massive amount of buearocratical bullshit .. sorry about the spelling .. read alot but still can't spell ..
so what do you think bob ??? if you would like to read further on the net . put in a search with nucleus accumbens dopamine .. mesolimbic system dopamine .. give me your thoughts .. thanks much ..laura
poster:LAURA777
thread:138954
URL: http://www.dr-bob.org/babble/20030204/msgs/139866.html