Posted by LAURA777 on February 5, 2003, at 15:50:49
In reply to Re: Provigil / Mirapex » Stan, posted by not exactly on February 5, 2003, at 13:25:19
Hey bob, i have been doing alot of research , and it seems to me my most basic problem is dopamine in the mesolimbic system , i have been reading and it seems some of us have a genetic error of reduction of the d2 receptors in the nucleus accumbens .. people who have this sooner or later become incapable to obtain gratification from the common pleasure of life ..
i further looked into it and found out of tests they did with the nucleus accumbens reguarding reward / punishment , and while the nucleus accumbens lit up or showed more activity when reward was anticipated it did not light up when punishment was atticipated , the medial caudate showed activity with punishment as well as reward too ..
this all meaning that positive and negitive feelings do not emulate from the same places in the brain .. because i can feel the negitive feelings like sad , boredom , ect ect. but when it comes to feeling pleasure anticipation exuberation , fun, these things are muted blunted .. have been for quite some time .. no interest and such ... people who are deficient in this area usually take up atypical and noxious pleasure .. impulsive gambling alcohol and drugs , eating excessive sweet foods , (i used to eat a ton when i was a kid ) alcoholism runs in my family as well as drug abuse...
i have taken up reading and working out my frontal lobe quite alot ... but this dampens too just like every addiction or diversion does ..
i need the other half of life !!!! the other half of emotions .. ya know .. anticipation stimulates motivation .. the menial tasks in my life are so much harder to do at times because i have nothing to temper it with .. am i explaining this right ???
i know this is responsible because of other culminating factors (this post would be too long}i know why people drink and take drugs , it is absolutly misrable in this state ..Unfortunately the path of addiction is also extremely painful and intolerable ... so what is one left to do ..
why do they not make a good dopaminergic damn it !!!!!! you see serotonin and nuroepinephrine where is the dopamine ???????? this is a real malady !!! you can pile on tons of ssris snris and whatever the hell , i know that i need dopamine .. i don't want to go supper high and i do not want to stay in the grey .. i want to cry .. anyone out there give me a hand !!!
i know the stimulants increase dopamine right where i need it .. but how does that work for a solution ??? do you build tolerance ?? what are the worse side effects ?? also from what i am reading about stimulants is that they are like MOAI's ... let me know , thanks in abundance and with gratefulness , laura
poster:LAURA777
thread:138954
URL: http://www.dr-bob.org/babble/20030204/msgs/139623.html