Posted by Ritch on December 13, 2002, at 22:32:10
In reply to Re: Can Klonopin decrease AD efficacy?, posted by MB on December 13, 2002, at 11:47:21
> I've been reading that there is an availability issue with Nardil, so I may not go that route either. I can't handle anything that blocks H-1 receptors (which brings on the restless leg syndrome I've had since a kid) so the tricyclics are kinda out (plus, I can't even take Allegra or Zyrtec, the "non-drowsey" antihistamines, without passing out for days on end). The only thing left for me to try is the MAOI thing. I'm doing this through my GP, so anything experimental like taking a stim with memantine (to avoid tolorance and dependence like last time) or trying a foreign drug like moclobemide is out of the question. Looks like it's Parnate or ECT or au natural. You know, now that I think of it, I haven't been chemical free for over 15 years...and what I mean by that is no p-meds, no rec-drugs, no caffeine, no alcohol, no psychotropics of any kind. I wonder what would happen if I just tapered off of EVERYTHING.
>
> I agree with you about taing meds to counter the untoward effects of other meds. The problem is that they all cycle in the system with different frequencies. I might need Klonopin to take the edge off of Wellbutrin SR, but if I take them at the same time, I'm going to be all over the place emotionally (i.e., at times the K levels will be low while the WB levels will be high; the K levels will be high while the WB levels are low; sometimes they'll both be in that perfect ratio; etc.) What I've been noticing is that I have violent rages with suicidal/homicidal ideation in the morning. These subside into relative normalcy by 10 AM. Then, by early afternoon, all I can do is cry like a baby...over nothing, really...I just weep like a school girl. Then around dinner time I'm back to relative normalcy with a tinge of hypomania. Then to bed to start the cycle over again. I'm almost SURE it is linked to the way the the ratios of the two drugs cycle over a 24 hr period. Plus, I still haven't been able to kick my caffeine habit, which makes this whole thing impossible to figure out.
>
> Plus, I'm so indecisive. Yesterday, I got that horrible AD dulling effect (the one where it feels like someone has drilled a hole in your forehead and filled your cranium with sand). Different than the Klonopin drowseys...I'm talking about that **sub-hallucinogenic-LSD-dose-put-me-on-the-short-bus-and-tie-my-shoes-for-me-what's-that-word-I-can't-remember** feeling. And I said, that's f*cking it, I want this crap out of my system. Then this morning, I think, "well, maybe it's helping a little," so I popped a WB tablet. I can't make up my mind and I'm rambling so I must not be *depressed* depressed, but it all seems so complex and difficult and not worth the effort and I just wish I didn't have go through the meaningless motions.
>
> MB
Wow!, you are having *ultradian* mood cycles. What sounds especially spooky is the early morning rage thing and then getting very depressed later on. That is not uncommon with folks with intermittent explosive tempers (like me-which at worst follows a rage/panic/depression sequence), but that is also not uncommon with temporal lobe epilepsy either. I think you went and did a bunch of SPECT scan stuff, right? What was the result of all that? You never replied about ever trying any Depakote---have you tried any? Just a hunch, but it sounds like you might benefit a lot from Depakote+T4 or something like it.
poster:Ritch
thread:131530
URL: http://www.dr-bob.org/babble/20021210/msgs/131743.html