Posted by Rick on October 25, 2002, at 22:24:26
In reply to Does Klonipin have dopamine effects, posted by linkadge on October 25, 2002, at 19:07:38
> For some reason I am under the impression
> that Klonopin has dopamine raising effects,Why is that? While many drugs can simultaneously have both pro and anti-dopaminergic effects, most studies have put Klonopin primarily in the latter category. Which in one way is odd, since both Klonopin and Dopamine Agonists are meds of choice in Restless Legs Syndrome.
> Kurt Cobain used this drug (probably abused it)
> in his attempt to withdrawl from Heroin. In him it caused psychosis.Like many psychotropics, Klonopin can have paradoxical effects in certain people, especially when the dose is high and it's combined with other agents. Even though Klonopin is sometimes used as an adjunct mood stabilizer, the following is an example of where it apparently induced mania:
DICP 1991 Sep;25(9):938-9
Mania associated with clonazepam.
Dorevitch A.
Faculty of Medicine, Hadassah Hebrew University, Jerusalem, Israel.
Clonazepam is a potent, long-acting benzodiazepine approved for use in myoclonic and petit mal seizures. Initial reports have demonstrated encouraging results with clonazepam in the treatment of acute mania as well as a favorable side-effect profile. A trial of adjunctive clonazepam was initiated in a 41-year-old patient with chronic schizophrenia. Two weeks later, while on an 8-mg dosage, he became manic, developing pressured speech, euphoria, inflated esteem, agitation, and insomnia. Initiation of electroconvulsive therapy with gradual tapering and discontinuation of the clonazepam resulted in amelioration of the manic episode and a return to his previous clinical status. Clinicians should be alerted to the potential of clonazepam to cause manic-like behavior in susceptible patients.
Rick
poster:Rick
thread:124171
URL: http://www.dr-bob.org/babble/20021025/msgs/125258.html