Posted by Geezer on September 13, 2002, at 10:45:32
In reply to Re: Fewer s/e with Lexapro - where's the evidence?, posted by sjb on September 13, 2002, at 9:11:12
>Hi sjb,
Very good point. The only drug studies carried on over a prolonged period of time, with significant numbers of participants, are conducted in Europe - the results are not admissible here in the US.
I had the experience of weight gain with Prozac (25 lbs over 4 years), D/Ced Prozac at 60mg. (cold turkey with no withdrawal). In a later trial of Remeron 30mg. + Depakote 1000 I only gained 10lbs (quit cold turky no withdrawal). Yet a later trial of Zoloft 200mg., no weight gain or loss and no withdrawal. I recently added Serzone 250 to Wellbutrin 400 and have lost 10 in three weeks (no gain or loss on Wellbutrin - only when Serzone was added).
The real point is I have TRD and would welcome any kind of relief from depression. I am not real concerned about side affects because I don't have any that are sever, probably because nothing works. I think real answers about side effects and efficacy will only come when we have true emperical testing (genetic markers, blood tests, and intracellular ADs). I know current meds. work well for most people, also believe the rest of us make up that 15% mortality figure every year. We get tired of rolling the dice for no benefit.
Prozac was the only AD that ever gave relief but pooped out.
Best of luck,
Geezer
You know, I really wish we had more long term studies. My experience, along with many others, proves a BIG difference in the first 6 weeks of treatment, and how one does after months (or years) on the same drug. I know it's expensive, etc, but remember when we heard that Prozac suppresses apetite? Many found this affect short lived and actually could lead to weight gain in the long run. I also caution folks on this board turning to Topomax for weight loss, as I believe that this, too, is short lived for some people.
poster:Geezer
thread:109458
URL: http://www.dr-bob.org/babble/20020906/msgs/119729.html