Posted by Shawn. T. on July 25, 2002, at 20:02:36
In reply to Re: downregulation??, posted by Shawn. T. on July 25, 2002, at 18:40:39
Here's an interesting study on panic disorders:
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=29148518Note that the mysterious reticular activating substance referred to is probably arachidonic acid; I don't know why they don't just call it that. Because Remeron has effects on GABA receptors as well as other anxiety relieving receptors, I believe it is a better choice than benzodiazepines, which are very addictive.
Here's a study that helps me understand why I experienced panic attacks on Paxil:
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=29834771
With drugs like Paxil and Zoloft, the 5-HT2A/2C receptors experience an increase in activation due to the increase of serotonin in the synapse.
My sister was taking 100mg/day of Zoloft, and she had several seizures. She was fired from her job because of this (in a clear violation of the ADA). Drugs like Remeron, which block 5-HT2A/2C receptors, are much safer. I do not understand why the American public tolerates the terrible quality inherent in many of the drugs on the market. Remeron may make you sleepy initially, but if you only take 7.5mg/day for the first two weeks, you will not have to deal with the sleepiness for long. I really see no need for anyone to start off taking more (especially not 30mg, that is just not clear thinking), but I am not their doctor and cannot tell them what to do. Sure, if you start off with a high dose, you are going to feel horrible. I had a much easier time adjusting to Remeron than Paxil. SSRI's are dirty, unselective drugs, and they often cause just as much harm as good. I don't know how many times I am going to have to post this message on this board before people realize the problems inherent in SSRI's. What is it going to take?More about the GABAb antagonist Baclofen: it isn't very effective for panic disorder. It is, however, useful in Tourette's syndrome:
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=16088143It also appears to be very useful in treating withdrawal symptoms.
poster:Shawn. T.
thread:113408
URL: http://www.dr-bob.org/babble/20020725/msgs/113730.html