Posted by Ritch on July 18, 2002, at 22:20:22
In reply to Re: slowed thoughts, posted by Geezer on July 18, 2002, at 11:00:09
> Hey Mitch,
>
> I called Lilley about 3 weeks ago. All they would tell me is they have a "target release date" of 2003. If what I have read is correct, Duloxatin should have a 50%-50% effect on serotonin and norep. from the first dose. With Effexor, it is my unserstanding, you have to wade through a lot of serotonin effect before you get to the norep. Correct me if I am wrong.
>
> Geezer
Hi,I was reading a post here recently that mentioned the transporter affinity ratios for Effexor and Cymbalta (duloxetine). Effexor is supposed to have approx. 30x more affinity for serotonin reuptake transporters than NE reuptake transporters, whereas duloxetine is supposed to have approx. 9x more affinity for serotonin reuptake transporters than for NE reuptake transporters. So, I view Effexor and duloxetine as SSRI's that also happen to block NE reuptake to a significant extent. And that's what Effexor *feels* like, anyhow. I have heard all of the stuff about boosting the Effexor dosage to get to a more significant NE reuptake. UGGH, I can't go there, because what is happening is Effexor probably "flattens" out on its ability to block reuptake of serotonin at some point (a saturation effect) and then the blockade of NE reuptake continues to increase significantly with further increased doses. Yuck. I would rather take a selective NE reuptake inhibitor, that happens to block reuptake of serotonin to a *lesser* extent, AND just take a *low* dose of *that* one antidepressant.
Mitch
poster:Ritch
thread:91928
URL: http://www.dr-bob.org/babble/20020718/msgs/112850.html