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Wellbutrin extrapyramidal effects?

Posted by Anna Laura on June 19, 2002, at 7:42:17


I started Wellbutrin about four weeks ago (also taking Effexor, 150 mg.)
I began taking 150 mg. the first week, then i went on 300 mg. the second week.
I'm on 450 mg. since yesterday.
I didn't experience anxiety or inner tension at all, just felt a little spacey the first couple of days.
After a few days i began to feel something, namely my 12 years anhedonia began to vanish and i was experiencing a calm, mild pleasurable feeling; it felt like my childhood depression sort of, and that was a positive sign to me since i had recovered from that type of depression; unfortunately that positive feeling didn't last. Just after the vanishing of the positive effect, i began to experience a transient extrapyramidal symptom, namely an involuntarly twiching of the tongue. Could this symptom be related to dopamine depletion?
I'm aware Bupropion is generally thought to be a dopaminergic drug, nonetheless, i read somewhere that 's a partial agonist, meaning has both agonistic and antagonistic properties, thus blocking and enhancing dopamine at the same time; moreover, it was especially designed not to induce any "high" or pleasurable feeling. A few studies outlined the weak dopaminergic effect of the drug.
Can some of you guys relate to those findings at all? Or may be my dopamine receptors are to blame, possibly having been depleted by a long lasting anhedonia?


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poster:Anna Laura thread:110261
URL: http://www.dr-bob.org/babble/20020617/msgs/110261.html