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Re: Accutane effects ??? » adamie

Posted by JohnX2 on May 12, 2002, at 15:51:40

In reply to Re: Accutane effects ??? » JohnX2, posted by adamie on May 12, 2002, at 15:06:57

Wow , I don't know how it works in Canada, but in the US even the general practictioners will do a basic screening to test for things like hypothyroid (a common underlying cause of depression symptoms).

I would get a thorough physical exam. Also maybe you can look into seeing an endocrinolist.

Printing out the information and correlating it to
your symptoms is good ammunition to get the doctors to to take you seriously. An endocrinologist does this for a living (looking at the things state in the abstract, insulin levels, hypothryoid etc). If you see an endocrinologist you are much less likely to get push back as they get paid to look at these things.

I reiterate that I'm not very knowledgable in this area. It just seems logical to look at how the Accutane may have affected your body. And if it has may be best to treat those specific symptoms to improve your overall health and well-being.

Hope this helps,
John

>thanks for the info. quite the discovery. no i have not had a basic physical. how do i go about this? and how do u go about testing myself for hyperinsul and the hypercholes? how do i get tested for everything? the dirty doctors are so pissy about getting any tests done.
>
> what do i dooooooooooooooooooooooooo
>
> also i had yellow skin and my wounds dont heal so easily anymore. a tiny scratch can leave a scar. i cant print out all this stuff to show the doctor so i dunno what the heck to do.
>
>
>
>
> > Hi Adamie,
> >
> > Have you had a good basic physical to look for
> > hypothyroid, endocrinology , etc?
> >
> > This may be a total crap-shoot, take it for what
> > it is worth....
> >
> > But I found this abstract (below) regarding potential adverse effects of Accutane.
> > One of them, hyperinsulinemia can lead to insulin
> > intolerance and elevated glucose levels. The change
> > in vision you described would fit this (it is a precursor symptom
> > potentially to Type 2 diabetes, I believe)
> >
> > I also found this article regarding neurlogical
> > implications of hyperinsulinemia (not sure on quality
> > of information here):
> >
> > http://www.diabetesincontrol.com/issue78/item12.shtml
> >
> > Take Care,
> > John
> >
> > ----------------------------------------
> >
> > High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study.
> >
> > Rodondi N, Darioli R, Ramelet AA, Hohl D, Lenain V, Perdrix J, Wietlisbach V, Riesen WF, Walther T, Medinger L, Nicod P, Desvergne B, Mooser V.
> >
> > Department of Internal Medicine, CHUV University Hospital, University Medical Policlinic, CH-1011 Lausanne, Switzerland.
> >
> > BACKGROUND: Administration of 13-cis retinoic acid (isotretinoin) for acne is occasionally accompanied by hyperlipidemia. It is not known why some persons develop this side effect. OBJECTIVE: To determine whether isotretinoin triggers a familial susceptibility to hyperlipidemia and the metabolic syndrome. DESIGN: Cross-sectional comparison. SETTING: University hospital in Lausanne, Switzerland. PARTICIPANTS: 102 persons in whom triglyceride levels increased at least 1.0 mmol/L (> or =89 mg/dL) (hyperresponders) and 100 persons in whom triglyceride levels changed 0.1 mmol/L (< or =9 mg/dL) or less (nonresponders) during isotretinoin therapy for acne. Parents of 71 hyperresponders and 60 nonresponders were also evaluated. MEASUREMENTS: Waist-to-hip ratio; fasting glucose, insulin, and lipid levels; and apoE genotype. RESULTS: Hyperresponders and nonresponders had similar pretreatment body weight and plasma lipid levels. When reevaluated approximately 4 years after completion of isotretinoin therapy, hyperresponders were more likely to have hypertriglyceridemia (triglyceride level > 2.0 mmol/L [>177 mg/dL]; odds ratio [OR], 4.8 [95% CI, 1.6 to 13.8]), hypercholesterolemia (cholesterol level > 6.5 mmol/L [>252 mg/dL]; OR, 9.1 [CI, 1.9 to 43]), truncal obesity (waist-to-hip ratio > 0.90 [OR, 11.0 (CI, 2.0 to 59]), and hyperinsulinemia (insulin-glucose ratio > 7.2; OR, 3.0 [CI, 1.6 to 5.7]). In addition, more hyperresponders had at least one parent with hypertriglyceridemia (OR, 2.6 [CI, 1.2 to 5.7]) or a ratio of total to high-density lipoprotein cholesterol that exceeded 4.0 (OR, 3.5 [CI, 1.5 to 8.0]). Lipid response to isotretinoin was closely associated with the apoE gene. CONCLUSION: Persons who develop hypertriglyceridemia during isotretinoin therapy for acne, as well as their parents, are at increased risk for future hyperlipidemia and the metabolic syndrome.
> >
> > PMID: 11955026 [PubMed - indexed for MEDLINE]


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URL: http://www.dr-bob.org/babble/20020510/msgs/106115.html