Posted by adamie on May 12, 2002, at 15:06:57
In reply to Re: Accutane effects ??? » adamie, posted by JohnX2 on May 12, 2002, at 4:16:28
thanks for the info. quite the discovery. no i have not had a basic physical. how do i go about this? and how do u go about testing myself for hyperinsul and the hypercholes? how do i get tested for everything? the dirty doctors are so pissy about getting any tests done.
what do i dooooooooooooooooooooooooo
also i had yellow skin and my wounds dont heal so easily anymore. a tiny scratch can leave a scar. i cant print out all this stuff to show the doctor so i dunno what the heck to do.
> Hi Adamie,
>
> Have you had a good basic physical to look for
> hypothyroid, endocrinology , etc?
>
> This may be a total crap-shoot, take it for what
> it is worth....
>
> But I found this abstract (below) regarding potential adverse effects of Accutane.
> One of them, hyperinsulinemia can lead to insulin
> intolerance and elevated glucose levels. The change
> in vision you described would fit this (it is a precursor symptom
> potentially to Type 2 diabetes, I believe)
>
> I also found this article regarding neurlogical
> implications of hyperinsulinemia (not sure on quality
> of information here):
>
> http://www.diabetesincontrol.com/issue78/item12.shtml
>
> Take Care,
> John
>
> ----------------------------------------
>
> High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study.
>
> Rodondi N, Darioli R, Ramelet AA, Hohl D, Lenain V, Perdrix J, Wietlisbach V, Riesen WF, Walther T, Medinger L, Nicod P, Desvergne B, Mooser V.
>
> Department of Internal Medicine, CHUV University Hospital, University Medical Policlinic, CH-1011 Lausanne, Switzerland.
>
> BACKGROUND: Administration of 13-cis retinoic acid (isotretinoin) for acne is occasionally accompanied by hyperlipidemia. It is not known why some persons develop this side effect. OBJECTIVE: To determine whether isotretinoin triggers a familial susceptibility to hyperlipidemia and the metabolic syndrome. DESIGN: Cross-sectional comparison. SETTING: University hospital in Lausanne, Switzerland. PARTICIPANTS: 102 persons in whom triglyceride levels increased at least 1.0 mmol/L (> or =89 mg/dL) (hyperresponders) and 100 persons in whom triglyceride levels changed 0.1 mmol/L (< or =9 mg/dL) or less (nonresponders) during isotretinoin therapy for acne. Parents of 71 hyperresponders and 60 nonresponders were also evaluated. MEASUREMENTS: Waist-to-hip ratio; fasting glucose, insulin, and lipid levels; and apoE genotype. RESULTS: Hyperresponders and nonresponders had similar pretreatment body weight and plasma lipid levels. When reevaluated approximately 4 years after completion of isotretinoin therapy, hyperresponders were more likely to have hypertriglyceridemia (triglyceride level > 2.0 mmol/L [>177 mg/dL]; odds ratio [OR], 4.8 [95% CI, 1.6 to 13.8]), hypercholesterolemia (cholesterol level > 6.5 mmol/L [>252 mg/dL]; OR, 9.1 [CI, 1.9 to 43]), truncal obesity (waist-to-hip ratio > 0.90 [OR, 11.0 (CI, 2.0 to 59]), and hyperinsulinemia (insulin-glucose ratio > 7.2; OR, 3.0 [CI, 1.6 to 5.7]). In addition, more hyperresponders had at least one parent with hypertriglyceridemia (OR, 2.6 [CI, 1.2 to 5.7]) or a ratio of total to high-density lipoprotein cholesterol that exceeded 4.0 (OR, 3.5 [CI, 1.5 to 8.0]). Lipid response to isotretinoin was closely associated with the apoE gene. CONCLUSION: Persons who develop hypertriglyceridemia during isotretinoin therapy for acne, as well as their parents, are at increased risk for future hyperlipidemia and the metabolic syndrome.
>
> PMID: 11955026 [PubMed - indexed for MEDLINE]
poster:adamie
thread:106056
URL: http://www.dr-bob.org/babble/20020510/msgs/106112.html