Posted by Ron Hill on April 22, 2002, at 15:44:31
In reply to SAM-e dosage question for Ron » Ron Hill, posted by BarbaraCat on April 22, 2002, at 12:28:27
Barb,
> I currently take 2 blister pak SAM-e with 500 mg glucosamine included (Joint Action by Nature's Made). I want to try increasing it, but am unclear as to whether to take all of it at once or in divided doses.
You can do it either way, but divided doses provide at least two advantages that come to mind:
1. Less nausea (if that's a problem for you).
2. Provides more even blood levels throughout the day. However, do not take last dose past about 5 or 6 pm to avoid possible SAM-e induced insomnia.
>When, before a meal or with? Is it important to take the B vitamins along with the dose(s) or can they be another time of the day?
Take vitamins with meal. Take SAM-e on relatively empty stomach. Currently I take one dose of 200 mg per day, but at one time I was taking 400 mg/day in a divided dose. Here is what my "divided dose schedule" looked like:
1. Get up in the morning and eat a good healthy breakfast within thirty minutes of rising.
2. Immediately after breakfast, take oral (down-the-hatch) vitamins followed by sublingual (under the tongue) B-12.
3. Wait for an hour or so, and then take a 200 mg tablet of SAM-e. This wait time is important because SAM-e is adsorbed in the small intestines more effectively if there is not food present to compete for absorption. IMHO, I think it is important to have the B vitamins in the body ready and waiting for the SAM-e dose, but this opinion may fall under the category of "Another One of Ron's Baloney Theories".
4. About mid-afternoon, at least an hour after lunch and at least an hour before dinner, I take my second 200 mg tablet of SAM-e
>Also, where do you get the methylcobalamin? I take B-12 injections of cyanocobalamin because of my fibromyalgia/chronic fatigue. I've heard that that form is bound to cyanide and a no-no in general. I'd like to continue the injections (pills don't get assimilated in my gut), but can't find the methyl form anywhere, nor does my pharmacist know of a source. I'd settle for methyl sublingual but haven't found a source yet.
I buy my supply at a local Living Earth nutrition store, but you can obtain it at a number of on-line stores. Here is the link to one such store, but you may want to use a search engine to find others and compare prices.
http://www.vitaminshoppe.com/search/results.jhtml;$sessionid$YACHYOSMCAZZRQFIAI0CF3WAVABDEI5G?_DARGS=%2Fglobal%2Fleft_column%2Fleft_column.jhtml
-- Ron
poster:Ron Hill
thread:103077
URL: http://www.dr-bob.org/babble/20020416/msgs/103829.html