Posted by JohnX2 on April 17, 2002, at 20:24:15
In reply to Re: Update » JohnX2, posted by judy1 on April 17, 2002, at 17:43:56
> Wow, I would be higher than a kite on that combo. Lamictal made me hypomanic, well maybe manic and I can't take serzone. Topomax made me feel stupid- isn't that interesting that you had the opposite effect? Are you sure the serzone doesn't mess up your cycling? If you have pain, do any of the 'normal' pain-killers work? Like narcotics- also great AD. Take care, Judy
Hi Judy,
*Thanks* for your support.
I seem to be one of a few "lone gun-man" on Topamax cognition. No stupidity. But at the strong dose it makes me very agitated and we have come to the conclusion that it fuels hypomania pretty bad. A great adjunct for depression. When I lower the dose I feel mild atypical depression and less agitation.
It seems as though my headaches/pain are exacerbated by serotonergic medicines. Zoloft was really bad. Serzone blocks nasty serotonin receptors, which then increases dopamine in an area of the brain where dopamine dampens contractions of facial muscles. Topamax and Klonopin help to, but they work by slowing serotonin conductance (SWAG). I grew tolerant to Klonopin, which was a Godsend when I found it (the pain was excruciating). A lot of people complain of SSRI induced tension headaches and bruxism (jaw tension).
Lamictal at the higher doses also does this to me; I don't know why but it does seem to have serotonergic properties from some reports that I have read. This limits my ability to push the Lamictal dose to 150 mg (so no hypomania). Maybe with more Serzone, I can push the Lamictal too...Serzone in the past has no bad manic or poop out for me (without a mood stabilizer, unique) and for some reason with Lamictal it isn't making me drugged out. Go figure. Last time on Serzone I was so drowsy and fender-bendered my car and said I would never touch it again. Strange how the meds interact.
So hope is higher Serzone will alleviate residual mild depression and pain, and ditch Topamax.
Just a turkey shoot. Pretty close to hitting the home stretch, if I need to do Lithium so be it, but I think this is worth a quick shot (less medicine is more..)
Never thought about narcotics...
Regards,
John
poster:JohnX2
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URL: http://www.dr-bob.org/babble/20020416/msgs/103367.html