Posted by JohnX2 on March 24, 2002, at 17:22:54
In reply to Re: NMDA antagonist neurotoxicity » JohnX2, posted by christophrejmc on March 24, 2002, at 12:08:18
I've seen reports of it happening with the more competitive antagonists. I haven't seen anything indicating that Memantine would cause an olney's lesion? Could you direct me to some info on that?
That medicine (memantine) has been in Germany for like 10 yrs+ and I don't think there has been case reports of Olney lesions from it.DXM (dextromethorphan) on the other hand is quite toxic at strong doses. That medication with dxm in it better monitor the blood levels very closely. I would be leary about the neurotoxicity, yes.
John
> What is your take on NMDA antagonist neurotoxicity ("Olney's Lesions")? I could only find a few articles on MedLine, but I haven't looked too hard. Have you seen any reports of this with NMDA antagonist use? I believe it has been shown to happen with memantine/dextromethorphan/etc. As far as I know, it's only theoretically possible in humans, but it is kind of scary.
>
> -chris
poster:JohnX2
thread:99188
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