Posted by Ron Hill on March 24, 2002, at 13:51:59
In reply to Re: Dexedrine Dysphoria - SAME-e to the rescue? HE » Ron Hill, posted by Jerrympls on March 24, 2002, at 4:19:59
> Ron-- I take just a basic time-release B-complex vitamin. What's the deal with having to take the B-12 sublingually?
Most people do not effectively absorb B-12 when it is taken orally (down-the-hatch). Taking it sublingually (under the tongue) transfers the B-12 directly to the bloodstream, thereby, circumventing the low absorption associated with oral administration. Continue to take you B-complex, just add sublingual bioactive B-12 (methylcobalamin) to the vitamins you are currently taking.
>Does it really help that much? Might jus tthe B-12 help w/ energy???
Have you heard of people having much more energy and a better mood after going to the doctor to get a B-12 shot? While I am holding the B-12 under my tongue, I can literally feel a calming/focusing effect ocurring in my brain. Further, read the following article and then get in the car and go buy some sublingual bioactive B-12 (methylcobalamin). Do it now!
Your brainchemistry issues may require more fire power than SAM-e can bring to bear. Or, on the other hand, SAM-e may be just the ticket. Please post your dx and a list of your current meds so I can have a better idea if SAM-e would be expected to solve your problem.
Supercharged SAM-e: B Vitamins, Folate Increase the Supplement’s Effectiveness
by ImmuneSupport.com Staff12-01-1999 - Homocysteine is a sulfur-containing amino acid involved in several important methyl and sulfur transfer reactions, and is actually beneficial in small amounts. When homocysteine levels begin to rise in the body, excessive accumulation of homocysteine in the body fluid compartments is normally prevented by degradation through two enzymatic reactions called transsulfuration and remethylation. These two processes have to be functioning for homocysteine to be kept in control and for SAM-e to function in the body. Importantly, these same enzyme reactions cannot occur without proper levels of folate, vitamin B 6 (pyridoxal 5- phosphate), and vitamin B12 (cobalamin). If you take SAM-e to promote better health (lighter mood, comfortable joints and a detoxed liver), you also need adequate levels of B vitamins and folic acid to help the SAM-e do its job.
When the body has proper levels of folic acid, Vitamins B6 and B12, the enzymatic break-down of homocysteine occurs either through remethylation, which converts it into methionine, the SAM-e building block; or through transsulfuration, which turns it into glutathione, a powerful antioxidant.
But when those processes become sluggish, the homocysteine levels in the body begin to rise. Large homocysteine levels left unchecked in the body, become an invitation to disease, including heart attack, stroke, cancer, birth defects, depression and perhaps CFS and FM.
A published Swedish study showed results of which demonstrate consistently high homocysteine levels and low concentrations of vitamin B12 in the cerebrospinal fluid (CSF) of patients meeting established clinical criteria for Chronic Fatigue Syndrome and Fibromyalgia.
Those taking SAM-e should be aware that the healthy benefits they experience are not due to SAM-e alone. SAM-e may be the “team leader” however, folic acid, vitamin B6 and vitamin B12 are crucial members of the team that contribute to its success. It is only by incorporating the entire team that one can achieve the victory of better health and well-being.
Source:
Evarts, Jeremy Lucius. “New Study Links Fibromyalgia and Chronic Fatigue Syndrome to Low Vitamin B12 and High Homocysteine in Cerebrospinal Fluid.” Healthwatch, August 1998.
Cowley, Geoffrey and Underwood, Anne. "What is SAMe?" Newsweek, July 5, 1999.
Brown, Richard, M.D., Bottigileri, Teodoro, Ph.D., Colman, Carol. Stop Depression Now. New York, 1999.
http://www.arthritissupport.com/track/goto/rtgoto30l.cfm
-- Ron
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poster:Ron Hill
thread:99601
URL: http://www.dr-bob.org/babble/20020322/msgs/99878.html