Posted by Ritch on March 23, 2002, at 11:19:48
In reply to Dexedrine Dysphoria - SAME-e to the rescue? HELP!, posted by Jerrympls on March 23, 2002, at 1:40:04
> Just in case you haven't read any of my recent posts, I"ll give you the low-down:
>
> Seroquel - 400mg (night)
> Desipramine - 200mg (night)
> Ambien - 10mg night
> Ativan - 1mg daily as needed
> SAM-e 400mg/day w/ B complex vit.
>
> First--DYSPHORIA! Ugh....I have these very strong but brief periods of dysphoria: stomach suddenly sinks and intense feeling of dread. These last a second or so scattered throughout the day. I can find no correlation to dosing times, etc. This dysphoria really scares me because I will be felling ok then all the sudden everything is terrible, dread overflows my thoughts, the bottom completely falls out......then I'm back to feeling ok again. WHAT IS THIS AND WHY!? I could be sitting with my friends laughing and out of the BLUE my stomach will drop, an overwhelming sense of dread will wipe over me and throw me through a dysphoric "wave" that lasts a couple seconds....but that's 2 seconds too long for me.
>
> At first I thought it had to do with Dexedrine not working to it's full potential - so I started SAM-e to see if it could help reverse the dysphoria lapses. I was up to 1600mg/day for a couple days (this stuff as everyone knows is terrible expensive) but I could take 20 SAM-e pills and feel nothing. I take it on an empty stomach with a B-complex vit. Right now I am only taking 400mg - but still nothing at all. I
>
> Long ramble longer, I need to hear from anyone - someone - about working with supplements like SAM-e to help with stimulant poop-out and the dreaded dysphoria.
>
> I know my dopamine system is probably running on low - but what can i do to replensih? If I tell my doc all this will he laugh me out of the office?
>
> Anyone? Elizabeth? JOhnX? Anyone? Anyone at all? Perhaps my med combo could be playing a part--for ex: would Seroquel reduce the effectiveness of Dexedrine? I'm already weary of the whole things with acidity and metabolism of dexedrine - but I have been drinking a lot of Diet Cherry Cokes too. I'm sure that stuff isn't good for me either.
>
> Ok I'll stop. Anyone? Please...I'm so frustrated and just need some help here...please.....thanks
>
> Jerry
Hi Jerry,It doesn't really sound like "dysphoria" it sounds like *panic* to me. Why do you need to take so much Seroquel? Desipramine can be pretty *buzzy* too. Tricyclics in general can cause crawly skin and momentary adrenaline rushes. In what order were your meds started? Was it desipramine, then dexedrine, then you got anxiety and insomnia and they started piling on the Seroquel, Ambien, Ativan? The last time I was on a stimulant (Adderall), I had anx. problems and we kept adding on different things to quell it. One was Risperdal and then Seroquel. I had to go off the Adderall and go back on Klonopin. Maybe you need to back off your dexedrine *slowly* and see if you start feeling better (without getting depressed).
good luck,
Mitch
poster:Ritch
thread:99601
URL: http://www.dr-bob.org/babble/20020322/msgs/99636.html