Posted by JohnX2 on March 26, 2002, at 18:15:21
In reply to modafinil: glutamate and gaba blockade 3, posted by JohnX2 on March 26, 2002, at 18:12:43
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8977135&dopt=Abstract1: Neurosci Lett 1996 Dec 6;220(1):5-8 Related Articles, Books, LinkOut
The vigilance promoting drug modafinil decreases GABA release in the medial preoptic area and in the posterior hypothalamus of the awake rat: possible involvement of the serotonergic 5-HT3 receptor.Ferraro L, Tanganelli S, O'Connor WT, Antonelli T, Rambert F, Fuxe K.
Institute of Pharmacology, University of Ferrara, Italy.
The effect of modafinil on endogenous gamma-aminobutyric acid (GABA) release in the medial preoptic area (MPA) and posterior hypothalamus (PH) and the role of local 5-HT3 receptors in this effect was investigated in the awake rat using in vivo microdialysis. Modafinil (30-100 mg/kg i.p.) dose-dependently decreased GABA release from the MPA, while only the 100 mg/kg dose markedly reduced GABA release in the PH. The modafinil (100 mg/kg) induced inhibition of GABA release in the MPA and the PH was partially counteracted by the 5-HT3 receptor antagonist MDL72222 (1 microM) when perfused locally alone or together with the non-selective 5-HT receptor antagonist methysergide (1 microM). Thus, the reduction of GABA transmission induced by modafinil in the MPA and in the PH, at least in part, involves local 5-HT3 receptors. The GABA release inhibition by modafinil in the above areas may be relevant for its vigilance promoting action.
PMID: 8977135 [PubMed - indexed for MEDLINE]
poster:JohnX2
thread:100358
URL: http://www.dr-bob.org/babble/20020322/msgs/100375.html