Posted by JohnX2 on March 22, 2002, at 0:45:52
In reply to Trying to follow what you wrote! » JohnX2, posted by Janelle on March 21, 2002, at 23:49:56
> Hi John,
>
> Okay, I THINK (repeat think!) I follow what you said about Remeron's unique action at the norepinephrine receptors.
>
> You wrote: "It [meaning Remeron] blocks a feedback receptor called the "alpha-2" norepinephrine receptor. This sits on the sending neuron and detects norepinephrine in the synapse."
>
> What is it that "sits on the sending neuron and detects norepinephrine in the synapse"? Is it the alpha-2 NE receptor that sits on the sending neuron and detects NE in the synapse?
>Basically you are correct. Most presynaptic neurons have such feedback type receptors. On the norepinephrine neurons they are generally coined "alpha-2".
> If so, I guess that even with a receptor sitting on it, the sending neuron can still send (the receptor doesn't cover up the neuron so to speak!)
That is correct.
>
> You also wrote "By blocking this receptor with medicine (Remeron), this causes the sending neuron to release more norepinephrine."
>
> Are you saying that Remeron blocks the alpha-2 NE receptor so it can no longer detect NE in the synapse and since the receptor can't tell if NE is in the synapse, the sending receptor releases more NE?
>Yes, you learn very quickly my friend.
> Thanks very much!
No problem.
Best Wishes,
John
poster:JohnX2
thread:99295
URL: http://www.dr-bob.org/babble/20020318/msgs/99387.html