Posted by Janelle on March 21, 2002, at 23:49:56
In reply to Re: REMERON vs. SERZONE questions: » Janelle, posted by JohnX2 on March 21, 2002, at 18:59:32
Hi John,
Okay, I THINK (repeat think!) I follow what you said about Remeron's unique action at the norepinephrine receptors.
You wrote: "It [meaning Remeron] blocks a feedback receptor called the "alpha-2" norepinephrine receptor. This sits on the sending neuron and detects norepinephrine in the synapse."
What is it that "sits on the sending neuron and detects norepinephrine in the synapse"? Is it the alpha-2 NE receptor that sits on the sending neuron and detects NE in the synapse?
If so, I guess that even with a receptor sitting on it, the sending neuron can still send (the receptor doesn't cover up the neuron so to speak!)
You also wrote "By blocking this receptor with medicine (Remeron), this causes the sending neuron to release more norepinephrine."
Are you saying that Remeron blocks the alpha-2 NE receptor so it can no longer detect NE in the synapse and since the receptor can't tell if NE is in the synapse, the sending receptor releases more NE?
Thanks very much!
poster:Janelle
thread:99295
URL: http://www.dr-bob.org/babble/20020318/msgs/99370.html