Posted by SLS on March 18, 2002, at 8:26:30
In reply to Re: dopamine receptor sensitivity, TD, poop out?, posted by JohnX2 on March 17, 2002, at 23:42:04
> I always wondered if adaptations in the dopamine receptor sensitivities account for the poop-out syndrome and the potential for TD etc.At first, the term "dopamine depletion" didn't seem right to me. Amphetamines cause dopamine depression, don't they? Dopamine is depleted because the neuron is forced to release more than it is designed to, compounded by the activation of the negative feedback loop. I wouldn't think that the few days it takes to develop tolerance is the result of changes in presynaptic receptor binding. Do you? Now, if SSRIs tend to result in a reduction of neuronal firings downstream, how does this result in depetion? Do you think the presynaptic regulatory system "atrophies", with some sort of reduction in the amount of machinery available to synthesize and release neurotransmitter. Is their less dopamine because so little is released? A bit paradoxical. I guess this could be defined as "depletion".
- Scott
poster:SLS
thread:98489
URL: http://www.dr-bob.org/babble/20020318/msgs/98573.html