Posted by JohnX2 on March 14, 2002, at 22:25:00
In reply to Re: SLS (Scott), anti-poopout agents? CCB's, posted by djmmm on March 14, 2002, at 14:02:36
djmm,The 5ht-2 receptor is gated to nmda recptors.
Activation of 5ht-2 receptors helps to fire the
nmda receptorWhen the nmda receptor is depolarized and fired, possibly calcium (Ca++) shoots through the tube and may be used in some genomic process (such as in long term potentiation/ learning/ etc).
Note: excess Ca++ flux is toxic.I'm not sure about serotonin syndrome. But from what I could find, the medicines used there that you described are 5ht-2 antagonists. They *block* serotonin from touching that 5ht-2 receptor, thus inhibiting nmda conductance.
The nmda antagonists that I was looking at like memantine, just try to prevent excessive Ca++ from flowing through the NMDA channel when it is activated. These medicines have been shown to potentially affect tolerance and sensitization to medications. If you dig through that web site, you will see some writing on it, and some animation of the process.
Also, Lamictal is a good anti-depressant for TRD, and it has been shown to mediate the electrophysical properties of these NMDA receptors and I have even seen a report that it increases brain levels of the amino acid taurine. Taurine is a mild nmda antagonist.
My interest in Acamprosate comes from the fact that it is a carrier moleculer for taurine (n-acetyl-homo-taurine) that readily crosses the blood-brain barrier. Taurine, at GNC, does not. Note, I believe Taurine has anti-epileptic properties.
Also, the clacium channel blocker article for
treatment resistant depression looked interesting and I also saw some fine articles written showing that CCB would prevent the development of some sensitization to cocaine. The CCB helps to prevent excessive gene transcription changes from what I understand.These are just my thought I could be wrong.
I typed this fast.-John
> >
> > use of calcium channel blockers in
> > ultra-rapid cylcling
> > nuerobiology treatment resistant depression
> >
> > http://www.acnp.org/g4/GN401000110/Default.htm
> >
> >
> > >
> > > Have you seen this Naltrexone anti-SSRI poop-out tip in the pbabble tips section? It look kind of hoky.
> > >
> > > But Naltrexone is an opioid-antagonist.
> > > And as you may now, these NMDA antagonists involved in synaptic plasticity mitigate opioid
> > > tolerance.
> > >
> > > So I don't if this is some kind of a "work-backwards" ploy but it looks intriguing.
> > >
> > > Btw, did you know that the 5ht-2 receptor is gated to NMDA conductance?
> > >
> > > Also, amphetamine releases serotonin via a diffusion mechanism at serotonin receptors.
> > >
> > > This whole poop-out thing is tied together in
> > > my shoot from the hip view.
> > >
> > > Maybe need more poop-out stabilizers?
> > >
> > > Something atypical:
> > >
> > > Naltrexone, Memantine,
> > >
> > > This other medicine Acamprosate (a GabaB med + NMDA antagonist) is fast track FDA approval for
> > > alcoholism for Forest Labs and is being looked at also for treatment resistant bipolar disorder (it is available in europe).
> > >
> > > I also saw some good darts at calium channel
> > > blockers like nimodipine.
> > >
> > > Still curious about this Naltrexone dude.
> > > Maybe you can reach that guy by email and find out what his thinking is?
> > >
> > > Best wishes,
> > > John
>
> "poop-out" has to be caused to *too* much serotonin...why do antagonists like buspar work?...seems like activating the 5-ht2 receptors relieves "poop-out" symptoms in many...
>
> Take a look at the symptoms of *too much* serotonin.
>
> 5ht2 acting drugs are given for serotonin syndrome...
>
> I wonder If *lowering* the SSRI dose (when symptoms first appear) would help?
poster:JohnX2
thread:97813
URL: http://www.dr-bob.org/babble/20020313/msgs/98058.html