Posted by paulb on February 25, 2002, at 18:38:44
In reply to anyone anxious on pindolol?, posted by JohnX2 on February 24, 2002, at 17:25:37
Pinodol may have caused you to become
hypomanic after 3 days, and then petered out because it blocks the 5-HT1a auto-receptors that control the release of serotonin. If they are blocked then more serotonin is released via a negative feedback loop. OOnce your brain adjusted to the increase in 5-HT then that may be the reason it petered out. Just a theory. But the auto-receptor blockade is what makes pinodol special among the beta-blockers. Blockade of the 5-HT1a post-synaptic receptors could also cause further serotonin activity at other receptor causing hypomania but propranalol has the same property so I would assume it was the auto-receptor blockade, an antidepressant mechanism comparable with MAO inhibition and monoamine re-uptake. Just think of Mirtazapine.
paulb
poster:paulb
thread:95338
URL: http://www.dr-bob.org/babble/20020222/msgs/95494.html