Posted by JohnX2 on February 20, 2002, at 21:14:54
Anyone hear of allergic depression/mania?I have a very interesting theory as to
why Serzone held up as an AD for me.Ok, how does this sound:
1) 3 yrs ago I developed 1st signs of serious
allergies in Austin, this was 6 months
before my serious mood problem. I also developed
inflammatory diseases.2) I always got weird anti-depressant responses.
On Zoloft, my emotions would
go numb but then I would go manic and then my
emotions would go numb. On wellbutrin I was ok
but then I would go manic and then my emotions
would go numb. On Lamictal, I'm OK at 150 mg,
but when I go to 300 mg my emotions go numb.
Also, I always get a bad pressure in my head with the
numbing. I find a large dose of an anti-histamine
can relieve the pressure if I get "stuck".3) On Serzone, I was OK??? I never got "stuck".
I got an AD response, but I was overwhelmingly
drowsy and had to quit the AD. No mania.Ok, after reading up on how histamine regulates
neurotransmitters, trying to figure out how
I can feel so fantastic after trying a large
dose of the anti-histamine chlorpheniramine.
I just found by accident that this particular
anti-histamine works well at times.Now here is what the histamine receptors do
There is an interesting feedback loop, look at H3
(I'm still looking into this more):H1: Elicit increases in phosphoinositol hydrolysis;
H2: Mediated through increases in cyclic AMP; antagonists used to decrease gastric acid secretion.
H3: predominantly presynaptic, feedback inhibition of histamine, norepinephrine, serotonin, acetylcholine release. Possibly related to decreased intracellular calcium.
What is interesting is that there is a link between
serotonin and histamine production that I am still trying
to understand.So what if that H3 receptor got stuck ? that could
explain that bizzarro world I get into where my emotions
go numb and I get bad pressure in my head and a whopper
anti-histamine makes it go away.Klonopin and Topamax I have found ease the myofacial pain,
perhaps they (GabaA) regulate the histamine feedback somehow
too.Why is Serzone interesting? It is interesting
because one of its metabolites is a direct serotonin agonist.
It is called mCPP. Does this mean that Serzone can "break"
a messy malfunctioning feedback loop where histamine is
over or underproduced due to the feedback inhibition?If this is true it has serious ramifications for me.
It means I can use Serzone as an adjunct to get my
medicines to work. The mCPP metabolite would not be hurt
by the feedback and maybe this creates some kind of control
into the loop? Does this theory sound nuts?.Thoughts?
Anyways I should be thoroughly checked for
allergies. Austin is called the allergy capitol
of the world.-John
poster:JohnX2
thread:94861
URL: http://www.dr-bob.org/babble/20020215/msgs/94861.html