Posted by ray on January 25, 2002, at 14:29:48
In reply to Re: Zyprexa and MAOIs?, posted by OldSchool on January 24, 2002, at 20:26:46
I've pondered Parnate + Zyperexa in past.
Was based on 1 day trial of 2mg zyprexa add in (dr. gave me samples), maybe about 2 years ago.1)Added 2mg to Nardil 60 + Klonopin.
2)As expected got sedated.
3)Added 150 Wellbutrin.
4)Incredible. Dramatic effect rest of day.
Never thought more because too many meds but learned something.Currently trying low dose amisulpride.
Very interesting reminds me of zyperexa experience.
However not quite right with my regimen.
Cannot tolerate except very low dose (< 10mg/day!)Eldepryl makes sense. Decreases prolactin to counter amisulpride increase.
Eldepryl even low dose blocks sedation from tramadol for example, wheareas Nardil will not at 60mg, it will lead to increasing sedation and with enough tramadol serotonin syndrome (VERY BAD NEWS). (NOTE: NOT MAOI SCARE TACTIC, TRAMADOL + MANY ANTIDEPRESSANTS CAN LEAD TO SEROTONIN SYNDROME).
Anyway point being Eldepryl even low dose (perhaps even moreso than at higher dose), generally offsets anti-dopaminergic effect of anti-DA meds.Parnate inbetween Nardil and Elderpyl might go well with Zyprexa at very low dose.
Ray
> > Hi, thanks for the response. I was wondering if Zyprexa is the opposite of MAIOs. Does Zyprexa decrease the amount of dopamine and MAIOs increase it? I have a sort of a problem. I been taking Zyprexa for a speech problem because there have been tests that say that people who stutter have a higher level of dopamine the normal people and Zyprexa has been used to treat stutterers I also have a social aniexty order though and want to take something for that. So far, the Zyprexa hasn't been helping my speech, any ideas?
> >
> > David
>
> I dont know anything about stuttering or speech problems so Im not going to pretend to. That is a question for your doctor. But I can tell you that Zyprexa decreases the amount of dopamine AND serotonin. Zyprexa is a dopamine and serotonin antagonist.
>
> MAOIs on the other hand potently increase levels of both dopamine and serotonin, as well as a wide variety of other brain neurotransmitters. MAOIs increase everything basically.
>
> All anti-psychotics are dopamine antagonists...thus they block dopamine levels.
poster:ray
thread:91461
URL: http://www.dr-bob.org/babble/20020124/msgs/91566.html