Posted by CalvaryHill on January 11, 2002, at 0:37:20
In reply to WARNING!!! OFF ALL MEDS?!!!, posted by bob on January 10, 2002, at 21:21:09
I believe you can do well with one of two most tolerable MAOIs (which I have taken too with success):
Moclobemide (Aurorix):
I was thinking you could possibly take the MAOI/RIMA moclobemide, ordering it from outside the United States. It can be taken with your current regimen too. Moclobemide is a new MAO inhibitor antidepressant which differs from previous MAO inhibitors in two ways: its action on MAO is reversible and its inhibitory action is relatively selective for MAO-A. The drug is shortacting and increases brain concentrations of both noradrenaline and serotonin. Its interaction with dietary amines causes considerably less increase in blood pressure than occurs with the classical MAO inhibitors. It is an effective antidepressant which is relatively free of adverse effects.****Selegiline (Eldepryl), MAOI-B (mostly):
High-dose selegiline appears to be an effective therapy for treatment-resistant depression in out-patients. The epidemiologic data are clear that depression and suicidal behavior occur at high rates in TRD patients. It is also well documented that many of the side effects associated with traditional tricyclics prohibit their application in this population. Consequently, monoamine oxidase (MAO) inhibitors are often used by clinicians to treat the TRD patient. Sunderland and colleagues in the NIMH intramural program examined the efficacy of high-dose selegiline (formerly known as L-deprenyl) in treatment-resistant depressed patients. Of interest is the robust clinical improvement in depression with a daily dose of 60 mg of selegiline in only a 3-week clinical trial. This is a good response in a relatively short period and suggests an unusually rapid onset of action...Good luck to you, whatever you decide,
CalvaryHill
poster:CalvaryHill
thread:89666
URL: http://www.dr-bob.org/babble/20020110/msgs/89685.html