Posted by Magic on January 10, 2002, at 17:57:40
In reply to Re: Mirapex, Adrafinil, Amisulpride, posted by ChrisK on January 10, 2002, at 4:46:47
> I'm a big proponent of Mirapex. It has helped me incredibly with apthy/anhedonia. I've been on it for about 1 year now and don't have any problems at 4-5 mg/day. IMO more people should give this one a try.
>
> BTW, I take it with Nortriptyline and Zyprexa.I just started PPX 4 days ago (0.25 mg. TID), and I'm already having many side effects. They include exacerbation of various OCD symptoms and compulsive movements (not involuntary), RLS, insomnia, anxiety, mild agitation (most likely due to lack of sleep), spaced-out feeling, some dizziness and overall malaise. I'm supposed to increase it to 1.5 mg/day in one week, but I think I might have to start over at 0.125 TID first. I have some dopamine sensitization, too, from prior high-dose neuroleptic exposure, and can't tolerate dopamine antagonists. I'm wondering if PPX, even though it's a dopamine agonist, is causing the movement problems. The most bothersome is compulsive stretching and flicking of first two toes on left foot. SSRIs, trazadone, atypical APs and other drugs at doses beyond certain thresholds cause compulsive movements, too. (I know dopamine has been implicated in OCD.)
I'm trying to avoid ECT, and also use Trileptal, Lamictal, low-dose Valium and Celexa, and Aricept (as a mood stabilizer and cognitive enhancer). Trileptal and Lamictal help depression (losing their effect lately), and Celexa 20 mg/day helps OCD symptoms, but no longer depression.
Anyone have any suggestions for adjuncts to relieve these Mirapex-induced side effects (especially the movements and insomnia) or any other suggestions to help me give it an adequate trial at a therapeutic dose?
TIA...
poster:Magic
thread:89494
URL: http://www.dr-bob.org/babble/20020110/msgs/89633.html