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Desipramine and pain » BarbaraCat

Posted by CalvaryHill on January 9, 2002, at 1:26:20

In reply to Need your help! - another treatment failure, posted by BarbaraCat on January 8, 2002, at 17:13:19

Nortriptyline (a metabolite of amitriptyline) is a better drug overall for the prophylaxis of pain _and_ for anxiety--this is supported by the Psychopharmacology Tips. And nortriptyline has a benign side-effect profile that is comparable to desipramine.

Once you complete a trial with a TCA then the fatigue should dissipate because of norepinephrine dominance.

Your emotional lability concerns me, and your mood-stabilizer dose of Lithium is severely inadequate. I would suggest a trial with Divalproex to smooth out the cycles and also add an antidepressant effect.

Take Care,
CalvaryHill


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poster:CalvaryHill thread:89346
URL: http://www.dr-bob.org/babble/20020103/msgs/89395.html