Posted by SLS on November 30, 2001, at 7:43:58
In reply to Re: Morphine for depression. » SLS, posted by Elizabeth on November 30, 2001, at 1:18:38
> > Have you ever tried amantadine (Symmetrel)? It's a long shot, but if Lamictal helped a little, perhaps amantadine could help augment or reduce the induction of tolerance to opioids via NMDA receptor antagonism.
>
> I didn't know that about Lamictal or amantadine.Lamotrigine inhibits the release of glutamate, thereby reducing NMDA stimulation. Amantadine (a relative of memantine) blocks NMDA receptors. It was probably a dumb idea.
> I believe that the current thinking is that NMDA blockers don't really prevent tolerance, they just augment the opioid, alas.
I see.
> I've known a few people who used DXM to that end,
For opioid enhancement or for the prevention of desensitization? Did it work?
- Scott
poster:SLS
thread:84007
URL: http://www.dr-bob.org/babble/20011123/msgs/85610.html