Posted by JohnX2 on November 18, 2001, at 17:51:57
In reply to Re: new bupropion mode of action abstract- CAM,SLS,JG » JohnX2, posted by Mitch on November 18, 2001, at 17:35:00
Hi Mitch,Your experience is somewhat consistent with mine.
I can only sit down at best like 30 min out of 60
doingw ork because I can't sit still. Fortunately I
can get a shit load done in those 30 mins.
Sometimes its so bad I have to leave my building and drive my
car. For some reason "movement" calms me down.
I also feel compelled to get up and talk to
people. My doctor thinks this is more of a
mixed state in bipolar, but it seems more add to
me. Drinking a lot of caffeine helps me to stay
focused too. At one point before I entered the
world of psychiatry I was drinking 15+ diet cokes
a day and driving my car like 30k miles a year.
I would chase this at night with alcohol just
to calm me down. Eventually after many medication
failures I landed on a combo of Adderall + Klonopin.
I thought it was funny that basically all this
psychiatry did after 1 year was elevate
me from caffeine+alcohol to amphetamine+sedative. ;)I was fine on Adderall + Klonopin, but grew
tolerant to Klonopin and Adderall then made
me manic. I have a problem with wellbutrin when
I hit the therapeutic dose it kicks in , makes
me manic, and then peters out. But I can take
a sub-therapeutic dose to help calm my nerves,
stabilize my mood, and help with concentration.Glad to here that things are going well. I
wish you continued success.regards,
john> John,
>
> I also have noticed a significant reduction in the need to "keep moving" (my restlessness/akathisia). I also feel less "pressured" to get everything done all at once. I feel actually somewhat emotionally "neutral", and relaxed. I don't have fifty things all going at once. The dystonia (tight throat muscles) from the tiny bit of Zoloft I take seems to be less and I am not grinding my teeth as much. I even was focused enough to SIT STILL for two hours and set up my own mood chart on a spreadsheet.
> That is too bad you can't seem to get the WB to "work" for you. Maybe the nortriptyline you have been thinking about could kick-start it. I would take it at bedtime to start off, though. It is somewhat sedative (although I took it in the daytime, too in divided doses).
>
> Mitch
>
> >
> > Hey this is great news.
> >
> > I also get a *substantial*
> > anxiolytic response from Wellbutrin.
> > Supposedly it is effective
> > for peripheral neuropathy from a report
> > I recently read too.
> >
> > I really wish I could find
> > a way to make wellbutrin work. The only
> > other med that really cured my dysthymia was
> > Adderall and it had its problems. WB is a
> > good med if one can get it to work.
> >
> > I believe the anxiolytic action comes
> > from its action in the locus coerulus area
> > of the brain (the noradrenaline flight/fight)
> > area. It increase norepinephrine, but slows
> > down the firing which is usually anxiolytic.
> > A lot of people get edjy on Wellbutrin, so that
> > must be from some other interaction in the head,
> > because slowing the LC almost always
> > translates to less anxiety. Amphetamine
> > slows the LC too and some people actually feel
> > more calm on amphetamine than off amphetamine.
> >
> > regards,
> > john
> >
> >
> > > >
> > > > This is quite technical, but for those who are
> > > > interested:
> > > >
> > > > There was a new article in psychopharmocology
> > > > on Wellbutrin's mode of action.
> > > >
> > > > Basically came to some of the same conclusions as
> > > > another article I read, but also came up with 1 more
> > > > piece of data which I always thought would be true:
> > > > Bupropion increases serotonin conductance!
> > > >
> > >
> > > John, et al,
> > >
> > > I can't explain why I feel so much better, since I have added on a low dose of bupropion. I seem to have improved sleep architecture like I had on Adderall without feeling panicky. I don't seem to have the *avoidance* I used to have. I really seem to be getting a paradoxical *anxiolytic* response to this med. I also have needed less Klonopin-I only took 1/4 of a .5mg tab all day today! I should be getting very sluggish and melancholic now (SAD symptoms-late fall/early winter), but it isn't happening. The best way to sum this up is like taking a pstim with little anxiety. I notice some improvement with attention-but nowhere as marked as with a pstim. But, there is no *degradation* of cognitive function that I normally experience at this time of year.
> > > Go figure,
> > >
> > > Mitch
poster:JohnX2
thread:84499
URL: http://www.dr-bob.org/babble/20011113/msgs/84595.html