Posted by JohnX2 on November 18, 2001, at 13:33:53
In reply to Re: new bupropion mode of action abstract- CAM,SLS,JG » JohnX2, posted by Mitch on November 18, 2001, at 0:33:44
Hey this is great news.I also get a *substantial*
anxiolytic response from Wellbutrin.
Supposedly it is effective
for peripheral neuropathy from a report
I recently read too.I really wish I could find
a way to make wellbutrin work. The only
other med that really cured my dysthymia was
Adderall and it had its problems. WB is a
good med if one can get it to work.I believe the anxiolytic action comes
from its action in the locus coerulus area
of the brain (the noradrenaline flight/fight)
area. It increase norepinephrine, but slows
down the firing which is usually anxiolytic.
A lot of people get edjy on Wellbutrin, so that
must be from some other interaction in the head,
because slowing the LC almost always
translates to less anxiety. Amphetamine
slows the LC too and some people actually feel
more calm on amphetamine than off amphetamine.regards,
john
> >
> > This is quite technical, but for those who are
> > interested:
> >
> > There was a new article in psychopharmocology
> > on Wellbutrin's mode of action.
> >
> > Basically came to some of the same conclusions as
> > another article I read, but also came up with 1 more
> > piece of data which I always thought would be true:
> > Bupropion increases serotonin conductance!
> >
>
> John, et al,
>
> I can't explain why I feel so much better, since I have added on a low dose of bupropion. I seem to have improved sleep architecture like I had on Adderall without feeling panicky. I don't seem to have the *avoidance* I used to have. I really seem to be getting a paradoxical *anxiolytic* response to this med. I also have needed less Klonopin-I only took 1/4 of a .5mg tab all day today! I should be getting very sluggish and melancholic now (SAD symptoms-late fall/early winter), but it isn't happening. The best way to sum this up is like taking a pstim with little anxiety. I notice some improvement with attention-but nowhere as marked as with a pstim. But, there is no *degradation* of cognitive function that I normally experience at this time of year.
> Go figure,
>
> Mitch
poster:JohnX2
thread:84499
URL: http://www.dr-bob.org/babble/20011113/msgs/84580.html