Posted by Mitch on November 16, 2001, at 23:50:24
In reply to Re: Looks like Wellbutrin-hey generic is cheap! » Mitch, posted by JohnX2 on November 16, 2001, at 14:32:43
>
> Mitch,
>
> Good luck with the Wellbutrin. I got the generic
> pills by accident once because the pharmacy
> messed up, they were a lot cheaper. I think
> the sustained release needed for WB is overblown.
> The parent compound bupropion hcl has a short
> 1/2 life and is not believed to be responsible
> for the anti-depressant effect. One of its
> metabolites, in particular hydroxy-bupropion has
> an average 1/2 life of ~20 hrs. Usually a 20 hr
> half life means once a day dosing. I split the
> dosing into 2x a day to be safe. I don't do
> well with 3x a day, I forget in the afternoon
> or it is inconvienent.
>
> I don't think the manufacturer of WB would
> want people to have this information however.
> The scare about the seizures, which is totally
> overblown IMHO, drives people to the sustained
> release version which is conviently still covered
> by patent protection!
>
> Good luck, hopefully no side-effects!
> keep up posted.
>
> -johnHi John,
I agree 100% about the SR version being questionably superior. I still feel the "crash" during the day (on either one). I am now at 1/4*75mg 3x daily (starting today). I notice less fluctuation in energy level this way. I notice the shorter parent drug half-life however is what gives me the best attentional improvement. I am certainly not upset however, that the longer-halflife metabolites are more responsible for the AD effect. But, in my case the ameliorating ADHD effect is what I am striving for mainly and if by *default* I dose adequately for an AD prophylaxis-then so much the better. The ability to sleep OK and even *better* on this med really surprises me. I got drowsy last nite earlier than usual and went to sleep-no trouble at all. Slept soundly with no early morning awakenings. Had some recallable dreams, but not an excessive amount. A good 7-8 hrs. sleep. I have noticed an improvement in sociability at work that I hadn't expected. I don't feel "chilly or aloof" towards people like I did on the Adderall.
Also, I took my morning dose and jumped on the stairmaster for a strong workout and I didn't get any headaches like I did on the Adderall. My resting HR is elevated, however. But, not by much.Mitch
poster:Mitch
thread:83504
URL: http://www.dr-bob.org/babble/20011113/msgs/84466.html