Posted by JohnX2 on November 16, 2001, at 14:32:43
In reply to Looks like Wellbutrin-hey generic is cheap! » JohnX2, posted by Mitch on November 15, 2001, at 23:31:03
Mitch,Good luck with the Wellbutrin. I got the generic
pills by accident once because the pharmacy
messed up, they were a lot cheaper. I think
the sustained release needed for WB is overblown.
The parent compound bupropion hcl has a short
1/2 life and is not believed to be responsible
for the anti-depressant effect. One of its
metabolites, in particular hydroxy-bupropion has
an average 1/2 life of ~20 hrs. Usually a 20 hr
half life means once a day dosing. I split the
dosing into 2x a day to be safe. I don't do
well with 3x a day, I forget in the afternoon
or it is inconvienent.I don't think the manufacturer of WB would
want people to have this information however.
The scare about the seizures, which is totally
overblown IMHO, drives people to the sustained
release version which is conviently still covered
by patent protection!Good luck, hopefully no side-effects!
keep up posted.-john
> > I did try modafinil (provigil) once. It made me
> > much less edgy than Adderall for a comparision.
> > It works fast, so within a week you would know
> > whether or not to punt it.
> > Wellbutrin actually reduces my anxiety. The modafinil
> > had a short lived anti-depressant effect which
> > petered out after a few hours leaving me with a
> > too much coffee type tension headache. But this
> > has been a repeatable pattern for *me*. Your
> > results may vary.
> >
> > anyways good luck and let me know how
> > things go,
> >
> > john
>
>
> John,
>
> I started 1/4 of a 75mg generic tab of bupropion twice daily in addition to my current meds (Neuron./Klon./Zoloft). I am to titrate that upwards every few days to a provisional "max" of 100mg/day. I could barely tell that I took it-which is a *good* sign! I think my med sensitivities are actualy signals from my body/brain that certain substances aren't really being tolerated well and perhaps maybe I should reconsider them. My pdoc confirmed your Zoloft discussion about motor functioning and dopamine interference ("Zoloft is the worst offender BTW"). Nothing was suggested for an SSRI swap at this time, though (perhaps because the dosage is already so low and SSRI's worsen my cycling-maybe an SSRI discontinuation may be in the future?).
>
> Mitch
poster:JohnX2
thread:83504
URL: http://www.dr-bob.org/babble/20011113/msgs/84432.html