Posted by Mitch on November 7, 2001, at 13:30:08
In reply to Re: other stuff » Mitch, posted by Elizabeth on November 7, 2001, at 10:45:02
> Did you take several measurements while you were on each drug?
Oh yes-there was a clear correlation and not only that but it was also accompanied by increased resting heart rate, too. My resting HR (not on the meds mentioned)is normally around 60bpm. When I was on Effex. or NT or any TCA for that matter it tends to get elevated up to around 75-80.
> > Elizabeth, ANY antihistamine *wrecks* my attentional capacities. Remeron whacked it, so does nearly all the sedative TCA's, OTC antihistamines, etc.
>
> Like Benadryl, ChlorTrimeton, etc.? What about the non-drowsy ones (just curious)?Yes, Benadryl, etc. Well, Claritin didn't, but that is a selective peripheral antagonist. Let me think...Well I tried Seldane and it made me "wired", restless, and fogged up, yuck.
>
> > NT, in summary is the only TCA I have tried that doesn't make me *profoundly* dizzy, confused, or anxious.> Which others have you tried? Ever think about getting your hands on some reboxetine? Also...did you get a serum level on the nortriptyline?
TCA's: doxepin, amitriptyline, nortripytline, desipramine. Also, see my post in the TCA survey thread.
Yes, done serum level on NT once and it was subtherapeutic-BUT I wasn't taking an SSRI with it at the time (cyp2d6), and I waited too long after the last dose.
Reboxetine-I think that might be a perfect low-dose augment to my low-dose Zoloft. Not available here in U.S., though. I think it's cousin-tamoxetine is soon to be approved for ADHD though and I will definitely bring that one up to my pdoc if they get it approved.
> As for the dizziness, my experience has been that it subsides after a little while. The start low/go slow approach might help with something like this (although it can be frustratingly slow for those of us who aren't very patient < g >).I was on doxepin for about four years, amitriptyline for about two-never seemed to shake the tachycardia and orthostatic hypotension. NT is the only one that seems to have minimal OH (even less than Remeron-which I tried for a few months the first time around).
I just thought of it, but I had some very intense "dizzy spells" on Prozac (just a few). They were so bad I had to stay on the floor for a few minutes and I wasn't sure I could drive and almost called in to work-but it passed.whew!
>Did SSRIs or other serotonergic drugs ever make >you peevish or hostile?No, in general they (SSRI's) tend to make me smiley and cheerful, but often can cause akathisia and heighten "startle" type reactions. When I was taking Buspar it was to reduce some of the restlessness caused by Celexa and improve GAD-type symptoms. Well, as I brought the Buspar dose up from 5mg > 10mg I became very very dysphoric and hateful, talking to myself a lot, and nearly became physically violent on several occasions. Don't know if it was from serotonin agonism, whatever. All I know is that the only thing that I can find in common with Remeron is the alpha-2 antagonist activity. And I got very very nasty and hateful on Remeron as well. Interestingly on Remeron I also developed a mild stutter or vocal tic at times.
Mitch
poster:Mitch
thread:82248
URL: http://www.dr-bob.org/babble/20011104/msgs/83447.html