Posted by JohnX2 on October 31, 2001, at 11:41:36
In reply to Re: Modafinil test day, posted by JohnX2 on October 31, 2001, at 11:18:07
man, my grammar/spelling is atrocious when I read
my posts after the fact. Good thing
I didn't major in english. I hope this doesn't
ding me for reliability of information. I type
really fast, that is my excuse. ;)-john
>
> Oh yeah,
>
> Here is my main concern about the memanine
> pitch. If I approach the doctor with my experience
> on Adderall and is I explain how dxm is like
> memantine, then he might start to get suspicious
> that I am abusing street drugs or dxm on the
> side, WHICH I AM NOT. I would prefer to get
> a robust anti-depressant response from something
> that worked before like Zoloft or Wellbutrin and
> without the weirdism and poopout. Anyways the
> neurologist he referred me to suggest a muscle
> relaxant baclofen, and memantine is actually
> listed as a skeletal muscle relaxant in the
> Merck Index of chemical/meds. So the to recommendations
> coincide. I also think it may be worthwhile to
> compine acamprosate with memantine. There could
> be synergistic action. PS. Forest Labs of
> celexa fame (soon to be off patent) is
> acquiring the rights for both acamprosate and
> memantine in the US; I wonder where they'll go with it?
>
> -john
>
>
>
>
> >
> > Hi Scott,
> >
> > Ok. Here's where I'm at.
> >
> > xxxxxxx-dm is just generic robitussin-dm.
> > If you look at the ingredients 1 tsp is
> > equivalent to 10mg of dextromethorphan hydrobromide.
> > Theoretically, if you read those patents, and
> > I can email the docs to you as I did to JG
> > (they include all the images), I could pull
> > a prozac or nortryptyline trick to mimick
> > memantine (i.e. increase the 1/2 life substantially
> > of dxm to allow a small 30mg once or twice a
> > day dosing). Dextromethorphan is a well studied
> > medication and has the "similar" properties as memantine.
> > It just has a crummy half-life and can cause
> > dissacciative effects and potentially Olney's
> > lesion (which is discussed in detail in one of
> > those patents). So, I would really prefer to
> > test memantine.
> >
> > So basically, I have found that if instead of
> > using the shotgun approach of testing meds, which
> > I did at first, and instead tried to find meds
> > that treated my physical ailments that could also
> > by coincidence treat my depression/hypo-mania, then
> > I have had more luck.
> >
> > I have discussed in many of my
> > threads my logical conclusion regarding my
> > facial pain and bizarre anti-depressant responses.
> > I have studied and found a clear trend between
> > the anti-depressants that help with the anhedonia
> > and pain *without* poop-out and have also looked
> > carefully at the better anti-depressants for
> > my anhedonia, specifically wellbutrin. I have
> > also looked extensively to try to understand why
> > I experience this damn medication poop out.
> >
> > Here is the most common demonitor:
> > NMDA receptor activity. Activity in the
> > Ventral Tegmental Area and how the dopamine
> > is sensitized and dispersed to the frontal
> > cortex or limbic system (nucleus accumbens).
> > The med that pulled me out of depression
> > was Lamictal a glutamate stabilizer via
> > electrolyte balancing. The nmda antagonists
> > are different as they can "tame" pathological
> > nmda activation and calcium release that is
> > not supposed to be there and which I believe
> > is causing some sort of down stream adjustment
> > that causes the med poop out.
> >
> > So where to go from here.
> > Meds that worked for pain:
> >
> > Serzone,Zyprexa 5ht-2a,alpha-1 antagonists
> > these receptors are somehow coupled to glutamate
> > relese and hence nmda activations. Ergo, stimulation
> > activates the nmda receptors. A dysfunctional
> > chronic stimulation could lead to some exhaustion,
> > sensitization,who nows what. The antagonists
> > of the 5ht-2a receptors I believe are taming
> > the nmda receptors to give a more "repeatable"
> > firing pattern and better "tone" in my brain's
> > complecated feedback system.
> >
> > Adderall is a sympathomemetic dopamine and sertonin releaser
> > and a potent dopamine reptake inhibitor. It works
> > for me *wildy* for a day and slowly craps out over
> > 3 days. Modafinil, caffeine work for a few hours
> > before they quit (assuming a interim med vacation).
> >
> > Where is my dysfunction? I have no clue. I just
> > see a trend. I think my dysfunction is in the LC,
> > and I believe meds like Tenex and Clonidine may
> > also help to resychronize my brain. I have exhausted
> > the anti-convulsants and need to think outside the
> > box. So my brain is telling me to go after the source.
> > Why do I get poop-out from stims in a short span
> > of time? I don't know, but it is probably glutamate
> > related. So, what if I interrupt the sensitization
> > process using well backed up statistical data on
> > nmda antagonists and my own tinkering with robitussin
> > to try to attack the most common chemical in the
> > brain directly?
> >
> > Will it work. I don't friggin know. But I am
> > forever an optimist and trying my damndest not
> > to give up. Maybe I won't hit paydirt. But I
> > would prefer to use some deductive reasoning
> > to pick my meds since this is my nature as
> > a human being, left-brained, engineering geek
> > instead of continuing this assinine shot-gun
> > approach. "we don't know how the medicine works"
> > is no longer acceptable to me.
> >
> > So that's about it.
> >
> > What do you think? I hope you are having good
> > luck. I mean if you can't sustain a buzz on
> > amphetamines then some fundamental feedback
> > loop in your body is dysfunctional and needs
> > to be addressed. This is my opinion. I am very
> > opinionated. I think there is a good reason why
> > you also did well on Lamictal and the anti-psychotics.
> > I was looking into correlations on the other meds
> > you took and started to find some, but it just
> > seemed you should try the most novel approach
> > (and with few side effects to boot).
> >
> > PS. I can email all my relavant documents
> > related to the amphetamine sensitization
> > theories and also the bruxism paper. They
> > seem to jive. I also have the patents which are
> > interesing to read. You just need to download
> > the cpc viewer (a special viewer for these compressed
> > documents) from cartesian (there is a link at
> > getthepatent.com). As a bonus I send a hilarious
> > patent on a "very different" type of anti-depressant.
> >
> > So what are you thinking?
> >
> > regards
> > john
> >
> >
> >
> > > Hi John.
> > >
> > > Could you summarize why you think memantine would be effective for you, how you would use it, and what you expect from it?
> > >
> > > Thanks.
> > >
> > > Also, what is "otc rxxxxxxxn-dm"?
> > >
> > > I have mentioned memantine to my doctor. He seems genuinely inquisitive. Perhaps you should call a few different doctors to see if they would be receptive to such things. I have never canvassed for doctors on the phone, and don't know how often you can get one to interview on the phone, but some people here have described success going about things this way.
> > >
> > > Take care.
> > >
> > >
> > > - Scott
poster:JohnX2
thread:81980
URL: http://www.dr-bob.org/babble/20011025/msgs/82767.html