Posted by JohnX2 on October 31, 2001, at 8:31:31
In reply to Re: Modafinil test day » JohnX2, posted by SLS on October 31, 2001, at 7:17:22
Hi Scott,Ok. Here's where I'm at.
xxxxxxx-dm is just generic robitussin-dm.
If you look at the ingredients 1 tsp is
equivalent to 10mg of dextromethorphan hydrobromide.
Theoretically, if you read those patents, and
I can email the docs to you as I did to JG
(they include all the images), I could pull
a prozac or nortryptyline trick to mimick
memantine (i.e. increase the 1/2 life substantially
of dxm to allow a small 30mg once or twice a
day dosing). Dextromethorphan is a well studied
medication and has the "similar" properties as memantine.
It just has a crummy half-life and can cause
dissacciative effects and potentially Olney's
lesion (which is discussed in detail in one of
those patents). So, I would really prefer to
test memantine.So basically, I have found that if instead of
using the shotgun approach of testing meds, which
I did at first, and instead tried to find meds
that treated my physical ailments that could also
by coincidence treat my depression/hypo-mania, then
I have had more luck.I have discussed in many of my
threads my logical conclusion regarding my
facial pain and bizarre anti-depressant responses.
I have studied and found a clear trend between
the anti-depressants that help with the anhedonia
and pain *without* poop-out and have also looked
carefully at the better anti-depressants for
my anhedonia, specifically wellbutrin. I have
also looked extensively to try to understand why
I experience this damn medication poop out.Here is the most common demonitor:
NMDA receptor activity. Activity in the
Ventral Tegmental Area and how the dopamine
is sensitized and dispersed to the frontal
cortex or limbic system (nucleus accumbens).
The med that pulled me out of depression
was Lamictal a glutamate stabilizer via
electrolyte balancing. The nmda antagonists
are different as they can "tame" pathological
nmda activation and calcium release that is
not supposed to be there and which I believe
is causing some sort of down stream adjustment
that causes the med poop out.So where to go from here.
Meds that worked for pain:Serzone,Zyprexa 5ht-2a,alpha-1 antagonists
these receptors are somehow coupled to glutamate
relese and hence nmda activations. Ergo, stimulation
activates the nmda receptors. A dysfunctional
chronic stimulation could lead to some exhaustion,
sensitization,who nows what. The antagonists
of the 5ht-2a receptors I believe are taming
the nmda receptors to give a more "repeatable"
firing pattern and better "tone" in my brain's
complecated feedback system.Adderall is a sympathomemetic dopamine and sertonin releaser
and a potent dopamine reptake inhibitor. It works
for me *wildy* for a day and slowly craps out over
3 days. Modafinil, caffeine work for a few hours
before they quit (assuming a interim med vacation).Where is my dysfunction? I have no clue. I just
see a trend. I think my dysfunction is in the LC,
and I believe meds like Tenex and Clonidine may
also help to resychronize my brain. I have exhausted
the anti-convulsants and need to think outside the
box. So my brain is telling me to go after the source.
Why do I get poop-out from stims in a short span
of time? I don't know, but it is probably glutamate
related. So, what if I interrupt the sensitization
process using well backed up statistical data on
nmda antagonists and my own tinkering with robitussin
to try to attack the most common chemical in the
brain directly?Will it work. I don't friggin know. But I am
forever an optimist and trying my damndest not
to give up. Maybe I won't hit paydirt. But I
would prefer to use some deductive reasoning
to pick my meds since this is my nature as
a human being, left-brained, engineering geek
instead of continuing this assinine shot-gun
approach. "we don't know how the medicine works"
is no longer acceptable to me.So that's about it.
What do you think? I hope you are having good
luck. I mean if you can't sustain a buzz on
amphetamines then some fundamental feedback
loop in your body is dysfunctional and needs
to be addressed. This is my opinion. I am very
opinionated. I think there is a good reason why
you also did well on Lamictal and the anti-psychotics.
I was looking into correlations on the other meds
you took and started to find some, but it just
seemed you should try the most novel approach
(and with few side effects to boot).PS. I can email all my relavant documents
related to the amphetamine sensitization
theories and also the bruxism paper. They
seem to jive. I also have the patents which are
interesing to read. You just need to download
the cpc viewer (a special viewer for these compressed
documents) from cartesian (there is a link at
getthepatent.com). As a bonus I send a hilarious
patent on a "very different" type of anti-depressant.So what are you thinking?
regards
john> Hi John.
>
> Could you summarize why you think memantine would be effective for you, how you would use it, and what you expect from it?
>
> Thanks.
>
> Also, what is "otc rxxxxxxxn-dm"?
>
> I have mentioned memantine to my doctor. He seems genuinely inquisitive. Perhaps you should call a few different doctors to see if they would be receptive to such things. I have never canvassed for doctors on the phone, and don't know how often you can get one to interview on the phone, but some people here have described success going about things this way.
>
> Take care.
>
>
> - Scott
poster:JohnX2
thread:81980
URL: http://www.dr-bob.org/babble/20011025/msgs/82750.html