Posted by JGalt on October 27, 2001, at 21:59:18
In reply to Re: Post Traumatic Stress Disorder and etc. » JGalt, posted by JohnX2 on October 27, 2001, at 15:41:06
I looked up the DSM-IV for PSTD, clearly is not me. I cannot think of a single event that was extremely traumatic at a young age. I had tons of mild to moderate things, but nothing in particular burned into my memory. No flashbacks or nightmares from my childhood that I remember either. I never have had good long term memory. The DSM-IV stated in such a case the cause was likely simple depression. Still might be worth it to look at the crf antagonists just for curiousity's sake.
The second you said jaw and headache problems, dopamine overload popped in my mind. Here's why. GHB greatly slows down (or perhaps stops) the release of dopamine in the brain. However, dopamine continues to be produced in the brain. After the GHB is metabolized, dopamine release resumes, but guess what, you got more dopamine there. No problem, just a pleasant stimulant effect. But never come all the way down from GHB and the dopamine keeps on building up and up to whatever limit there is. I know this because I've done it, twice. Logically what happens is then all that dopamine is released, you have less hunger, and more noticeably, painful headaches and jaw clamping. Too much dopamine. I'm guessing what is happening with you is you're having too much dopamine, then you take an AD such as wellbutrin, dopamine is released to the point that you have practically none left and you are left with the hypodopaminergic state. This would tend to suggest that you have 1. low dopamine storage capacity or 2. are very sensitive to dopamine agonists. Before you used the wellbutrin, the dopamine kept building up and up. Extreme excess of dopamine is hallmark of schizophrenia and mania. The interim period when taking the AD's that you feel relief is when dopamine is at a reasonable level of storage and being released at the same time, as happens in the theoretical normal person. Make sense or did I miss something? You know, now that I write this it occurs to me, why wasn't ghb ever used to treat bipolar syndrom? Since it prevents dopamine from being released, that gets rid of the mania as far as I understand it, and since during mania I don't believe your body stores more dopamine, it simply releases more. Just come down from it every 6 hours and all would be well, then use AD's while in the depressive state.
By the way, I did my research on GABA antagonists. It turns out that all the GABA antagonists we currently have are either non-specific, or carry a rather high risk of seizures, or they are not incredibly easy to purchase or store. All of them except for two. Adrafinil and Modafinil, though both of those are not complete antagonists except at inhuman dosages, I think 500-700mg would be sufficient as that is their believed method of action. So I guess my next theoretical mission if I were to want to pursue that regimine would be to take a 500-700mg dose of modafinil , then take some 1,4 butanediol. That much modafinil would easily be able to give me a headache due. If the 1,4 butanediol prevents this headache then 1,4 butanediol is a gaba agonist. Simple enough if I were to want to find out. I don't think I'd bother unless the curiousity strikes me hard enough someday. Really after I wrote out what I did above about GHB and dopamine, it would probably be a bad redundant to combine it with a dopamine agonist I would imagine if the uncompletely tested pharmacodynamics of ghb are correct.
I understand the idea behind lengthening DXM's effects. A drug with such powerful effects needs something to lengthen its halflife to be useful theraputically.
Hmm, if alpha-2 agonists were to help prevent onley's lesions, then logically beta-2 agonists would exacerbate them. Guess I have to throw out the ephedrine if I were to try it using a different gaba agonist such as one of the benzodiazapines.
I'll check up on that cpc reader and see if it works on a mac and get back to you.
Thanks again,
JGalt
poster:JGalt
thread:81980
URL: http://www.dr-bob.org/babble/20011025/msgs/82464.html