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Re: CAM: question about codeine and antidepressants » shelliR

Posted by SalArmy4me on September 11, 2001, at 18:38:46

In reply to CAM: question about codeine and antidepressants, posted by shelliR on September 11, 2001, at 18:03:52

Romach MK, Sproule BA, Sellers EM, Somer G, Busto UE Long-term codeine use is associated with depressive symptoms. J Clin Psychopharmacol 1999;19:373-6

"We found that long-term codeine users had elevated scores on a general measure of psychologic distress and that depressive symptoms were very common. Although it is not clear from our survey how much of this symptomatology preceded the codeine use and may have been an initiating factor and how much was a consequence of codeine use, we speculate that regardless, codeine was being used by many of these individuals to modulate mood in the absence of more appropriate interventions. The majority of users described using codeine for management of chronic pain, and chronic pain has been reported to be closely associated with depression, particularly in women. [14] The strong family history of depressive disturbances and the fact that more than half of the respondents had sought professional help for mental health problems (most often depression) support the importance of dysphoric mood states in association with long-term codeine use. Whether depression and anxiety in substance-dependent individuals are "independent" states or secondary drug-induced disorders, the clinical significance of making such a distinction with respect to treatment is unclear..."


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