Posted by jojo on August 24, 2001, at 11:44:39
In reply to Re: Temgesic » jojo, posted by JahL on August 24, 2001, at 9:54:28
> > > The various "races" aren't really as easily distinguishable as all that. In the USA, at least, most "black" people really have some "white" ancestry, for example. I was always in favour of the melting pot idea (i.e., the "races" aren't distinguished, we're all just human beings), but that's become unfashionable lately. :-P
>
> > That's why I put the word "race" in quotes. Whatever scientific meaning that it may posses is statistical and says nothing about the individual, but it does refer to one's chance of possessing certain genes, which has an effect on their disease susceptibility
>
> Hi jojo. It's not a mental illness but sickle-cell anaemia, which mainly affects 'black' people is an example that springs to mind.
>
> >and drug response, and is more than just being a fast or slow metabolizer. As to individual drug response, the proof is still in the pudding, as they say.
>
> > BTW, it sounds like you and JahL (don't know about Neal) would make really lousy heroin addicts.
>
> How do you mean? In terms of actual response or ability to handle side-effects (which wouldn't bother me if the stuff actually worked)?
>
> >Do either of you know if you respond to amphetamine with euphoria.
>
> No. Over time I sniffed the equivalent of yr average speed factory (*never* again) and all it did was make me talk crap & stay up days on end for clubbing purposes. MDMA is the only drug-illegal or otherwise-that's ever made me feel euphoric. And that only worked for a yr or so.
>
> >There was an article some years ago about that being a predictor of one's chance of responding to imipramine vs amitriptylene, if one was going to respond to one of them.
>
> I've read (& forgotten) something similar.
> Which did lack of euphoria predict? Amitript. is one of the few TCAs I didn't try.
>
> Thanks,
> J.JahL-
I meant in ability to handle side effects. Bup rolled off my back like water off of a duck's. No "side effects" to speak of, and I'm approaching 2 months, my previous record for not crashing after dropping a reasonably effective AD (Celexa). I'm taking about 0.9 mg./day intrnasally, and did so from day one. It does, however, alleviate a persistent pain in my neck, no Freudian meaning intended (but I know you Freudians out there don't really care if it was intended or not.)
In the published study (or was it a letter?) people who responded to amphetamine with euphoria responded positively to imipramine, but not to amitriptyline. If there was no euphoric response to amphetamine, they responded to amitriptyline, but not imipramine. To my knowledge, the study was never reproduced. Actually, it was pretty much ignored. I experience no euphoria from amphetamine, did not respond to imipramine, but did have a positive response to amitriptyline.
Although I have taken amphetamine, as an adjunct to ADs, at up to 35 mg. per day, for several years, it provides me no euphoria and no addictive potential, as far as I can judge. When I stopped it for three weeks I had no cravings, only my previous anergic state.
jojo
poster:jojo
thread:75246
URL: http://www.dr-bob.org/babble/20010822/msgs/76226.html