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Re: Depakote+Neurontin combo » MM

Posted by Mitch on August 17, 2001, at 9:04:32

In reply to Re: Depakote+Neurontin combo » Mitch, posted by MM on August 17, 2001, at 0:01:31

> So do you think you've found your "cocktail"? What does the *right* cocktail feel like? I know the meds can't do everything, but how much of an improvement does it make?

I think I am on the right *cocktail* as far as the mood stabilizers go: low-dose combo of Depakote-Neurontin-Klonopin. From what I have read here lately about Zonegran and Keppra they clearly don't appear any better. Also, for some people Lamictal seems to set off a lot of anxiety and some hypomanic episodes-so given that and the "rash threat" I will probably be sticking with these three for a while. Interestingly their mechanism of action are all related to GABA enhancement which makes sense since I have a lot of anxiety mixed in with it. The eternal problem is how to get some notable help with my ADHD and seasonal depressive bouts without worsening something else. Of the three the Neurontin helps the *most* with that, but not quite enough. I am also on 20mg of nortriptyline which is for that, but I can tell it is a little destabilizing (like all AD's). I really wonder if I could just add some T4 (thyroid hormone) maybe 50micrograms to the three mood stabilizers (ditch the AD) and that would be enough to quell the depression and improve my fatigue and attentional problems. But my current pdoc says NYET!. Well, it has been a while since the answer was no...maybe I will bring it up again next time??

> I read the above post about dopamine and serotonin deficiency, and I agree with one of the posters who said that the chemical imbalance theory doesn't seem to be the whole answer, but that is hard to accept in a way because I *want* it to be simple like that. I *want* them to be close to solving all my problems :D.


Ditto on that for sure. Well it could be worse! Imagine if you had all of these problems and was living in the 40's of 50's or something. I am clearly better with the Dep+Neurontin combo than I was with lithium..

Mitch


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